LivingGLP1
Study S001538

Cissus Quadrangularis (CQR-300®) and Dichrostachys Glomerata (Dyglomera®) Extracts Increase GLP-1 Levels and Inhibit Dipeptidyl Phosphate-4 Activity in Healthy Overweight and Obese Adults

Included trial: extracted dataClinicalTrials.gov recordStudy Protocol and Statistical Analysis Plan (PDF)

Registration

Registration
NCT06827002
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Phase
PHASE1; PHASE2
Masking
DOUBLE
Status
ACTIVE_NOT_RECRUITING
Enrollment
248
Start
2023-03-29
Primary completion
2026-02-23
Lead sponsor
University of Yaounde 1
Conditions
Obesity and Overweight; Appetite Regulation
Interventions
DRUG:Dichrostachys glomerata; DRUG:Cissus quadrangularia; DRUG:Dextrin; DRUG:Semaglutide (Rybelsus®)
Results posted
FALSE
Individual participant data sharing
YES
Secondary identifiers
OTHER_GRANT:JAOF122025; OTHER:N°2014/08/488/CE/CNERSH/SP; OTHER:BTC-JIRB2023-084

Registered primary outcomes

  • Effect of DGE and CQE on participants GLP-1 level [Baseline (Week 0), Week 4, Week 8, Week 12 and Week 16]
  • Effect of DGE and CQE on participants DPP4 activity [Baseline (Week 0), Week 4, Week 8, Week 12 and Week 16]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0020582Dichrostachys glomerata and Cissus quadrangularis Extracts Enhance GLP-1 Secretion and Inhibit DPP-4 Activity in Overweight and Obese Individuals: A Randomized Controlled Trial
Youovop J, Authorea Preprints
2025Randomized trialDOIcites ClinicalTrials.gov:NCT06827002
R0017997Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS.
van Bloemendaal L, The Journal of endocrinology
2014Narrative reviewPMID 24323912DOIregistry reference BACKGROUND:24323912
R0021242Adverse Effects of GLP-1 Receptor Agonists.
Filippatos TD, The review of diabetic studies : RDS
2014Nonrandomized studyPMID 26177483DOIregistry reference BACKGROUND:26177483
R0024598GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes.
Ahrén B, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
2004Narrative reviewPMID 15655721DOIregistry reference BACKGROUND:15655721