Study S001510

An Open-label, Single Arm, Sequential, Single Centre Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT02249910
Study type: INTERVENTIONAL
Allocation: NON_RANDOMIZED
Phase: PHASE1
Masking: NONE
Status: COMPLETED
Enrollment: 32
Start: 2014-09-18
Primary completion: 2015-03-06
Lead sponsor: Novo Nordisk A/S
Conditions: Diabetes; Healthy
Interventions: DRUG:semaglutide; DRUG:metformin; DRUG:digoxin; DRUG:placebo
Results posted: FALSE
Secondary identifiers: EUDRACT_NUMBER:2013-004820-12; OTHER:U1111-1150-0801

Registered primary outcomes

Area under the metformin plasma concentration-time curve [During a dosing interval (0 to12 hours) at steady state]
Area under the digoxin plasma concentration-time curve [From time 0 to infinity after single dose]

Linked records (1)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0017338	Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects. Bækdal TA, Clinical pharmacokinetics	2019	Other trial	PMID 30945118 DOI	registry reference BACKGROUND:30945118