Study S001299

IMPACT-MACS Study: Investigating the Mechanisms, Pathophysiology, and Cardiometabolic Treatment in Mild Autonomous Cortisol Secretion

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT07361874
Acronym: IMPACT-MACS
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: NONE
Status: RECRUITING
Enrollment: 75
Start: 2026-03-05
Primary completion: 2030-05-31
Lead sponsor: University of Texas Southwestern Medical Center
Conditions: Mild Autonomous Cortisol Secretion (MACS); Autonomous Cortisol Secretion (ACS); Subclinical Cushing's; Mild Autonomous Cortisol Excess
Interventions: PROCEDURE:Intervention 1: Adrenalectomy; DRUG:Intervention 2: Semaglutide
Results posted: FALSE
Individual participant data sharing: YES
Secondary identifiers: NIH:1K23DK142038-01A1

Registered primary outcomes

Change in Insulin Sensitivity (M-value), mg/kg/min [Baseline to Week 26]

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