Study S001005

GLP-1 Analogs for Neuroprotection After Out-of-hospital Cardiac Arrest, a Randomized Clinical Trail

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT02442791
Acronym: GLIP1
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: QUADRUPLE
Status: COMPLETED
Enrollment: 120
Start: 2014-06
Primary completion: 2016-06
Lead sponsor: Jesper Kjaergaard
Conditions: Cardiac Arrest; Coma
Interventions: DRUG:Byetta (Lilly, Exenatide); OTHER:20% Human Albumin
Results posted: FALSE

Registered primary outcomes

Feasibility: Over 90% initiation of study drug infusion [4 hours from return of spontaneous circulation]
Efficacy assessed by Area under the Neuron-specific Enolase curve [72 hours from admission]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0026326	Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients. Toftgaard Pedersen A, Scandinavian cardiovascular journal : SCJ	2022	Randomized trial	PMID 35546563 DOI	cites ClinicalTrials.gov:NCT02442791; registry reference DERIVED:35546563
R0016247	The Glucagon-Like Peptide-1 Analog Exenatide Increases Blood Glucose Clearance, Lactate Clearance, and Heart Rate in Comatose Patients After Out-of-Hospital Cardiac Arrest. Wiberg S, Critical care medicine	2018	Randomized trial	PMID 29189347 DOI	cites ClinicalTrials.gov:NCT02442791; registry reference DERIVED:29189347
R0016476	Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest: A Randomized Controlled Trial. Wiberg S, Circulation	2016	Randomized trial	PMID 27838646 DOI	cites ClinicalTrials.gov:NCT02442791; registry reference RESULT:27838646
R0020610	GLP-1 analogues for neuroprotection after out-of-hospital cardiac arrest: study protocol for a randomized controlled trial. Wiberg S, Trials	2016	Protocol	PMID 27363489 DOI	cites ClinicalTrials.gov:NCT02442791; registry reference DERIVED:27363489