Study S000894

The Effects of Semaglutide on Modulation of Taste Sensitivity, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Responses in Women With PCOS and Obesity: a Randomized, Single-blind, Placebo-controlled Clinical Trial

ClinicalTrials.gov record

Registration

Registration: NCT04263415
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: SINGLE
Status: COMPLETED
Enrollment: 30
Start: 2019-11-02
Primary completion: 2020-05-08
Lead sponsor: University Medical Centre Ljubljana
Conditions: PCOS; Semaglutide; Taste, Altered; Tongue Tissue Transcriptome; Gastric Emptying; Central Neural Response
Interventions: DRUG:Semaglutide; OTHER:Placebo
Results posted: FALSE
Individual participant data sharing: NO

Registered primary outcomes

to investigate the effect of semaglutide on taste perception as change in taste sensitivity detected by chemical gustometry evaluated with "Taste strips" test [Changes in taste perception from baseline up to the end of 12th week.]
CO-PRIMARY END-POINT : to investigate alteration of transcriptomic profile of human tongue tissue as changes in expression level from baseline to follow up after 12 weeks of treatment, measured by RNA sequencing [Change in transcriptomic profile from baseline up to the end of 12th week.]

Linked records (2)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0055574	6468 Once-Weekly Semaglutide and Taste Perception in Women with Obesity M Jensterle Sever, Journal of the Endocrine Society	2024	Randomized trial	DOI	cites ClinicalTrials.gov:NCT04263415
R0015032	Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial. Jensterle M, Trials	2021	Protocol	PMID 34281590 DOI	cites ClinicalTrials.gov:NCT04263415; registry reference DERIVED:34281590