Study S000866

Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease

Included trial: extracted data ClinicalTrials.gov record Study Protocol (PDF)Statistical Analysis Plan (PDF)

Registration

Registration: NCT03038620
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: QUADRUPLE
Status: COMPLETED
Enrollment: 235
Start: 2017-01
Primary completion: 2020-10-13
Lead sponsor: University of Texas Southwestern Medical Center
Conditions: Obesity, Visceral; Cardiovascular Diseases; Fat Disorder
Interventions: DRUG:Liraglutide; DRUG:Placebo
Results posted: TRUE
Individual participant data sharing: NO

Registered primary outcomes

Relative Percent Reduction in Visceral Adipose Tissue Mass Measured by MRI [Baseline, 40 weeks]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0023248	Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial. Neeland IJ, The lancet. Diabetes & endocrinology	2021	Randomized trial	PMID 34358471 DOI	cites ClinicalTrials.gov:NCT03038620; registry reference DERIVED:34358471
R0023762	Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Wadden TA, International journal of obesity (2005)	2013	Randomized trial	PMID 23812094 DOI	registry reference BACKGROUND:23812094
R0025439	Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Astrup A, International journal of obesity (2005)	2012	Randomized trial	PMID 21844879 DOI	registry reference BACKGROUND:21844879
R0027293	Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Astrup A, Lancet (London, England)	2009	Randomized trial	PMID 19853906 DOI	registry reference BACKGROUND:19853906