Study S000630

Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT07242534
Acronym: SEQ
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: NONE
Status: RECRUITING
Enrollment: 62
Start: 2026-01-19
Primary completion: 2027-02
Lead sponsor: Fundacion Dexeus
Conditions: Infertility; Obesity
Interventions: DRUG:Semaglutide; OTHER:No pre-treatment
Results posted: FALSE
Individual participant data sharing: UNDECIDED
Secondary identifiers: CTIS:2025-522525-34-00; NIH:2025

Registered primary outcomes

Number of good quality blastocysts (GQB) [Assessed once per participant, from oocyte retrieval (Day 0) to Day 5 of embryo culture, when embryos reach blastocyst stage.]

Linked records (10)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0002266	Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss. Sundararaman L, Journal of clinical medicine	2025	Narrative review	PMID 40142784 DOI	registry reference BACKGROUND:40142784
R0002458	The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation. Sola-Leyva A, Acta obstetricia et gynecologica Scandinavica	2025	Narrative review	PMID 39696822 DOI	registry reference BACKGROUND:39696822
R0003196	A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS. Bader S, Women's health (London, England)	2024	Systematic review	PMID 38444070 DOI	registry reference BACKGROUND:38444070
R0004398	Treating obesity and fertility in the era of glucagon-like peptide 1 receptor agonists. Goldberg AS, Fertility and sterility	2024	Narrative review	PMID 38810863 DOI	registry reference BACKGROUND:38810863
R0006356	Infertility Improvement after Medical Weight Loss in Women and Men: A Review of the Literature. Pavli P, International journal of molecular sciences	2024	Narrative review	PMID 38339186 DOI	registry reference BACKGROUND:38339186
R0005053	Do GLP-1 Analogs Have a Place in the Treatment of PCOS? New Insights and Promising Therapies. Szczesnowicz A, Journal of clinical medicine	2023	Narrative review	PMID 37762856 DOI	registry reference BACKGROUND:37762856
R0028870	Pharmacologic Treatment of Obesity in Reproductive Aged Women. Nuako A, Current obstetrics and gynecology reports	2023	Preclinical	PMID 37427372 DOI	registry reference BACKGROUND:37427372
R0023399	Once-Weekly Semaglutide in Adults with Overweight or Obesity. Wilding JPH, The New England journal of medicine	2021	Randomized trial	PMID 33567185 DOI	registry reference BACKGROUND:33567185
R0019254	The role of glucagon-like peptide-1 in reproduction: from physiology to therapeutic perspective. Jensterle M, Human reproduction update	2019	Nonrandomized study	PMID 31260047 DOI	registry reference BACKGROUND:31260047
R0025861	Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study. Salamun V, European journal of endocrinology	2018	Randomized trial	PMID 29703793 DOI	registry reference BACKGROUND:29703793