Study S000596

Effects of Liraglutide, Empagliflozin and Linagliptin on Mild Cognitive Impairment Remission in Type 2 Diabetes (LIGHT-MCI): A Multicentre, Randomised Controlled Trial With An Extension Phase

ClinicalTrials.gov record Study Protocol (PDF)Statistical Analysis Plan (PDF)

Registration

Registration: NCT05313529
Acronym: LIGHT-MCI
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: NONE
Status: COMPLETED
Enrollment: 396
Start: 2022-10-08
Primary completion: 2025-12-31
Lead sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions: Type 2 Diabetes Mellitus; Mild Cognitive Impairment
Interventions: DRUG:Liraglutide; DRUG:Empagliflozin; DRUG:Linagliptin
Results posted: FALSE
Individual participant data sharing: YES

Registered primary outcomes

Mild cognitive impairment (MCI) remission rate [The core study spans from baseline to 48 weeks]

Linked records (3)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0018433	Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase. Yu C, BMJ open	2025	Protocol	PMID 40840993 DOI	cites ClinicalTrials.gov:NCT05313529; registry reference DERIVED:40840993
R0022403	Enhancement of Impaired Olfactory Neural Activation and Cognitive Capacity by Liraglutide, but Not Dapagliflozin or Acarbose, in Patients With Type 2 Diabetes: A 16-Week Randomized Parallel Comparative Study. Cheng H, Diabetes care	2022	Randomized trial	PMID 35263425 DOI	registry reference RESULT:35263425
R0011068	Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies. Zhang Z, Diabetes care	2019	Other	PMID 31221697 DOI	registry reference RESULT:31221697