LivingGLP1
Study S000532

Effects of Single-dose Semaglutide on Cognition and Energy in Healthy Volunteers

Registration

Registration
NCT06363487
Acronym
OxSENSE
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
TRIPLE
Status
COMPLETED
Enrollment
70
Start
2024-06-06
Primary completion
2024-12-11
Lead sponsor
University of Oxford
Conditions
Cognitive Change
Interventions
DRUG:Semaglutide, 0.5 mg/mL; OTHER:Placebo, 0.9% NaCl 1.5mL
Results posted
FALSE
Individual participant data sharing
UNDECIDED

Registered primary outcomes

  • Reward (learning) [6-7 days]
  • Reward (effort-based) [6-7 days]
  • Reward (primary) [6-7 days]

Linked records (6)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0005203Glucagon-Like Peptide-1 Receptor Agonists
Collins L, StatPearls Publishing, Treasure Island (FL)
2024OtherPMID 31855395registry reference BACKGROUND:31855395
R0007247Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression.
Detka J, Pharmacological reports : PR
2021Narrative reviewPMID 34003475DOIregistry reference BACKGROUND:34003475
R0026671A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: Further link between metabolism and psychopathology: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
Pozzi M, Journal of affective disorders
2019Systematic reviewPMID 31153593DOIregistry reference BACKGROUND:31153593
R0022210Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials.
O'Neil PM, Diabetes, obesity & metabolism
2017Randomized trialPMID 28386912DOIregistry reference BACKGROUND:28386912
R0022960Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study.
Mansur RB, Journal of affective disorders
2017Other trialPMID 27721184DOIregistry reference BACKGROUND:27721184
R0019074Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes: Findings from the South London Diabetes (SOUL-D) Study.
Moulton CD, Primary care diabetes
2016Nonrandomized studyPMID 26137918DOIregistry reference BACKGROUND:26137918