Study S000493

Advancing ADPKD Treatment With GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT06582875
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE2
Masking: QUADRUPLE
Status: RECRUITING
Enrollment: 126
Start: 2025-03-06
Primary completion: 2029-06-30
Lead sponsor: University of Colorado, Denver
Conditions: Autosomal Dominant Polycystic Kidney; Obesity
Interventions: DRUG:Tirzepatide; OTHER:Placebo
Results posted: FALSE
Individual participant data sharing: YES
Secondary identifiers: NIH:R01DK138915-01A1

Registered primary outcomes

Change in height-Adjusted Total kidney volume [Baseline, 12-months]

Linked records (2)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0005160	The Need for Novel Therapeutic Directions in Autosomal Dominant Polycystic Kidney Disease Patient Care. Cortinovis M, Clinical journal of the American Society of Nephrology : CJASN	2026	Narrative review	PMID 41348481 DOI	cites ClinicalTrials.gov:NCT06582875; registry reference DERIVED:41348481
R0006150	Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease. Chen CY, Kidney360	2026	Other trial	PMID 41385299 DOI	cites ClinicalTrials.gov:NCT06582875; registry reference DERIVED:41385299