Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus

Registration

Registration

NCT03010683

Study type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Status

COMPLETED

Enrollment

60

Start

2015-11

Primary completion

2017-06

Lead sponsor

University of Athens

Conditions

Type 2 Diabetes Mellitus; Coronary Artery Disease

Interventions

DRUG:Liraglutide; DRUG:Metformin

Results posted

TRUE

Individual participant data sharing

NO

Registered primary outcomes

• Differences in Pulse Wave Velocity at Baseline and 3, 6 and 12 Months After Treatment With Metformin or Agonist GLP-1R. [Baseline, 3 months, 6 months and 12 months]
• Differences in Augmentation Index at Baseline and 3, 6 and 12 Months After Treatment With Metformin or Agonist GLP-1R. [Baseline, 3 months, 6 months, and 12 months.]
• Differences in Coronary Flow Reserve at Baseline and 3, 6 and 12 Months After Treatment With Metformin or Agonist GLP-1R. [Baseline, 3 months, 6 months, and 12 months.]
• Differences in Endothelial Glycocalyx Thickness at Baseline and 3, 6 and 12 Months After Treatment With Metformin or Agonist GLP-1R. [Baseline, 3 months, 6 months, and 12 months.]