Study S000230

The Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Biomarkers of Aging in Older Overweight/Obese Adults With Insulin Resistance

Included trial: extracted data ClinicalTrials.gov record Study Protocol and Statistical Analysis Plan (PDF)Informed Consent Form (PDF)

Registration

Registration: NCT05786521
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: NONE
Status: COMPLETED
Enrollment: 20
Start: 2023-04-01
Primary completion: 2024-05-20
Lead sponsor: The University of Texas Health Science Center at San Antonio
Conditions: Aging; Diabetes Mellitus, Type 2; PreDiabetes; Overweight and Obesity
Interventions: DRUG:Semaglutide Injectable Product; BEHAVIORAL:Lifestyle Counseling
Results posted: TRUE
Individual participant data sharing: NO
Secondary identifiers: NIH:5P30AG044271-08

Registered primary outcomes

Lean Body Mass Change [Baseline to 20 weeks]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0003242	Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis. Dinkla L, Frontiers in aging	2025	Randomized trial	PMID 41393101 DOI	cites ClinicalTrials.gov:NCT05786521
R0043856	GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS AND BONE HEALTH: RESULTS FROM A PILOT RANDOMIZED CONTROLLED TRIAL Dinkla, Lauren, WakeSpace Scholarship (Wake Forest University)	2025	Randomized trial		cites ClinicalTrials.gov:NCT05786521
R0007853	Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial. Cortes TM, JMIR research protocols	2024	Protocol	PMID 39269759 DOI	cites ClinicalTrials.gov:NCT05786521; registry reference DERIVED:39269759
R0049707	Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial (Preprint) TIFFANY M. CORTES	2024	Protocol	DOI	cites ClinicalTrials.gov:NCT05786521