Effects of Tirzepatide on Fat-Free Mass, Bone and Physical Function in Older Adults - a Pilot Study

Registration

Registration

NCT06861439

Acronym

GLOW

Study type

INTERVENTIONAL

Phase

PHASE4

Masking

NONE

Status

ACTIVE_NOT_RECRUITING

Enrollment

40

Start

2025-07-07

Primary completion

2027-10-30

Lead sponsor

Wake Forest University Health Sciences

Conditions

Obesity

Interventions

DRUG:Tirzepatide

Results posted

FALSE

Individual participant data sharing

NO

Registered primary outcomes

• Change in total body lean mass [Baseline to Month 9]
• Change in total body lean mass [Month 9 to Month 21]
• Change in appendicular lean mass [Baseline to Month 9]
• Change in appendicular lean mass [Month 9 to Month 21]
• Change in total body fat mass [Baseline to Month 9]
• Change in total body fat mass [Month 9 to Month 21]
• Change in total hip bone mineral density [Baseline to Month 9]
• Change in total hip bone mineral density [Month 9 to Month 21]
• Change in lumbar spine bone mineral density [Baseline to Month 9]
• Change in lumbar spine bone mineral density [Month 9 to Month 21]
• Change in 400 meter walk time [Baseline to Month 9]
• Change in 400 meter walk time [Month 9 to Month 21]
• Change in lower extremity physical performance score [Baseline to Month 9]
• Change in lower extremity physical performance score [Month 9 to Month 21]
• Change in leg strength [Baseline to Month 9]
• Change in grip strength [Baseline to Month 9]
• Change in grip strength [Month 9 to Month 21]
• Change in leg strength [Month 9 to Month 21]