Study S000003

LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide and Tirzepatide Therapy (LEAN-PREP Study)

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT06885736
Acronym: LEAN-PREP
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: SINGLE
Status: RECRUITING
Enrollment: 232
Start: 2025-08-07
Primary completion: 2029-08-30
Lead sponsor: Dasman Diabetes Institute
Conditions: Obesity
Interventions: BEHAVIORAL:Resistance exercise; DIETARY_SUPPLEMENT:Protein Intake
Results posted: FALSE
Individual participant data sharing: YES

Registered primary outcomes

MRI measured quadriceps cross sectional area (CSA) [From enrollment (at baseline) to the end of treatment at 6 months.]

Linked records (2)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0011371	LEAN mass Preservation with Resistance Exercise and Protein during semaglutide and tirzepatide therapy (LEAN-PREP study): a protocol for a randomised controlled trial. Alawadhi AA, BMJ open	2026	Protocol	PMID 42020128 DOI	cites ClinicalTrials.gov:NCT06885736; registry reference DERIVED:42020128
R0023498	Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined. Lundgren JR, The New England journal of medicine	2021	Randomized trial	PMID 33951361 DOI	registry reference BACKGROUND:33951361