{"columns":["prospero_id","retrieval","title","review_type","first_submitted","registered","versions","living","publication_status","country","full_protocol"],"rows":[["CRD42013005149","retrieved","Incretin based drugs for type 2 diabetes: an overview of systematic reviews","Systematic review of interventions","The record has not been submitted","24 July 2013","4","FALSE","Registered","Canada",null],["CRD42013005779","retrieved","The effect of lixisenatide on liver blood tests in patients with diabetes","Systematic review of interventions","The record has not been submitted","20 September 2013","1","FALSE","Registered","Denmark",null],["CRD42016036868","retrieved","Treatment with GLP1 receptor agonist reduces serum CRP concentrations in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","The record has not been submitted","23 March 2016","2","FALSE","Registered","China",null],["CRD42016038780","retrieved","Safety and efficacy of sulfonylureas compared to drugs with low risk of hypoglycaemia","Systematic review of interventions","24 November 2021","26 May 2016","2","FALSE","Registered","Estonia",null],["CRD42016039486","retrieved","Association of weight loss medications with cardiometabolic risk factors: systematic review and network meta-analysis","Systematic review of interventions","The record has not been submitted","23 May 2016","1","FALSE","Registered","United States of America",null],["CRD42016042063","retrieved","Effect of new antidiabetics on cardiovascular outcomes in type 2 diabetes","Systematic review of interventions","The record has not been submitted","03 July 2016","2","FALSE","Registered","China",null],["CRD42016043823","retrieved","Protocol of GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a NETwork meta-analysis (GLUCOSE DINET protocol)","Systematic review of interventions","05 July 2019","29 July 2016","2","FALSE","Registered","France",null],["CRD42017053952","retrieved","Efficacy and safety of a fixed-ratio combination of basal insulin and GLP-1 receptor agonist in T2DM patients","Systematic review of interventions","20 June 2018","22 December 2016","2","FALSE","Registered","China",null],["CRD42017057115","retrieved","Efficacy of glucagon-like peptide-1 receptor agonist as compared to dipeptidyl-peptidase-4 inhibitors for the treatment of type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials and interventional studies","Systematic review of interventions","The record has not been submitted","10 February 2017","1","FALSE","Registered","Canada",null],["CRD42017067889","retrieved","New anti-diabetic drugs and risk of stroke: a systematic review and meta-analysis of randomised controlled trials","Systematic review of interventions","04 July 2021","27 May 2017","2","FALSE","Registered","Scotland",null],["CRD42017071926","retrieved","Systematic review of clinical trial on incretin therapy in the perioperative period","Systematic review of interventions","The record has not been submitted","26 July 2017","1","FALSE","Registered","Australia, Netherlands",null],["CRD42017076625","retrieved","Pharmacologic therapy to induce weight loss in overweight and obese women with polycystic ovary syndrome: protocol for a systematic review and network meta-analysis","Systematic review of interventions","08 January 2018","17 October 2017","2","FALSE","Registered","England, China",null],["CRD42017079547","retrieved","Glucagon-like peptide-1 receptor agonist added to insulin versus basal-bolus or basal-plus in type 2 diabetes mellitus: a systematic review and meta-analysis on randomized controlled trials","Systematic review of interventions","15 December 2017","13 November 2017","4","FALSE","Registered","Italy",null],["CRD42018085967","retrieved","Comparative efficacy of anti-diabetic agents for treatment of cognitive impairment: a network meta-analysis of randomized controlled trials","Systematic review of interventions","16 January 2018","30 January 2018","2","FALSE","Registered","Canada, China",null],["CRD42018086446","retrieved","Efficacy of pharmacotherapy for obstructive sleep apnoea: a systematic review","Systematic review of interventions","18 January 2018","26 January 2018","3","FALSE","Registered","Switzerland",null],["CRD42018087262","retrieved","Efficacy  of glucagon-like peptide-1 analogues in the management of non-alcoholic fatty liver disease: a systematic review","Systematic review of interventions","27 January 2018","06 February 2018","3","FALSE","Registered","Ethiopia",null],["CRD42018087336","retrieved","Insulin treatment in type 2 diabetic patients and mortality","Systematic review of interventions","01 February 2018","06 February 2018","2","FALSE","Registered","Brazil",null],["CRD42018089761","retrieved","Effect of SGLT2 inhibitor monotherapy on weight changes in patients with type 2 diabetes mellitus: a Bayesian network meta-analysis","Systematic review of interventions","26 March 2018","05 April 2018","3","FALSE","Registered","China",null],["CRD42018090506","retrieved","Meta-analysis quantifying effects of GLP1 receptor agonists and SGLT2 inhibitors on cardiovascular risk factors, microvascular and macrovascular outcomes, adverse events, and mortality","Systematic review of interventions","06 March 2018","12 March 2018","3","FALSE","Registered","United States of America",null],["CRD42018091306","retrieved","Efficacy and safety of sodium-glucose co-transporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis","Systematic review of interventions","16 March 2018","19 March 2018","2","FALSE","Registered","England",null],["CRD42018091598","retrieved","Weekly semaglutide vs liraglutide efficacy and safety profile: a systematic review and network meta-analysis","Systematic review of interventions","19 March 2018","23 March 2018","2","FALSE","Registered","Saudi Arabia",null],["CRD42018094433","retrieved","Glucagon-like peptide-1 receptor agonists and fracture risk: a network meta-analysis of randomized clinical trials","Systematic review of interventions","20 April 2018","08 May 2018","6","FALSE","Registered","China",null],["CRD42018105193","retrieved","Cost effectiveness of sodium-glucose cotransporter 2 (sglt-2) inhibitors and glucagon-like peptide 1 (glp-1) agonists in treatment of type 2 diabetes patients who failed with metformin monotherapy: a systematic review and meta-analysis of economic evaluation studies","Systematic review of interventions","26 July 2018","14 August 2018","2","FALSE","Registered","India, Thailand",null],["CRD42018115577","retrieved","Cardiovascular outcomes, other safety issues and the efficacy of GLP1 receptor agonists in type 2 diabetes","Systematic review of interventions","02 November 2018","22 November 2018","2","FALSE","Registered","Italy",null],["CRD42019122043","retrieved","Long-term comparative effectiveness and safety of antidiabetic medications on patient important outcomes in patients with type 2 diabetes: protocol for a systematic review and network meta-analysis","Systematic review of interventions","16 January 2019","05 February 2019","3","FALSE","Registered","Greece",null],["CRD42019132807","retrieved","Personalizing type 2 diabetes mellitus treatment: benefits of different antihyperglycemic agents for cardiovascular prevention in patients with type 2 diabetes mellitus according to associated clinical conditions - meta-analysis of randomized clinical trials","Systematic review of interventions","24 June 2019","11 October 2019","1","FALSE","Registered","Brazil",null],["CRD42019138777","retrieved","The effects of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide 1 receptor agonists on cognitive functions in adults with type 2 diabetes mellitus: a systematic review and meta-analysis","Systematic review of interventions","12 June 2019","19 August 2019","2","FALSE","Registered","China",null],["CRD42019153180","retrieved","SGLT2 inhibitors and GLP-1 receptor agonists for type 2 diabetes: a systematic review with network meta-analysis of randomised controlled trials","Systematic review of interventions","02 October 2019","11 October 2019","1","FALSE","Registered","Australia, Canada, China, Italy, New Zealand, Scotland, United States of America",null],["CRD42020159284","retrieved","Values and preferences of patients with type 2 diabetes regarding the use of GLP-1 receptor agonists: A systematic review","Systematic review of interventions","21 November 2019","28 April 2020","1","FALSE","Registered","Mexico",null],["CRD42020165720","retrieved","Population-based observational studies of glucagon-like peptide 1 receptor agonists in type 2 diabetes exploring effectiveness and safety: a systematic review","Systematic review of interventions","16 January 2020","21 January 2020","3","FALSE","Registered","Scotland",null],["CRD42020168322","retrieved","Cardiovascular and renal outcomes of second-line antidiabetic drugs in patients with Type 2 diabetes: a systematic review and network meta-analysis of randomized controlled trials","Systematic review of interventions","10 February 2020","28 April 2020","2","FALSE","Registered","Malaysia",null],["CRD42020168351","retrieved","Predictive models for cardiovascular and kidney outcomes in patients with type 2 diabetes: systematic review and meta-analyses","Systematic review of interventions","07 February 2020","10 July 2020","2","FALSE","Registered","Canada",null],["CRD42020173199","retrieved","The effect of GLP-1 receptor agonists or in combination with metformin to weight loss in overweight and obese women with polycystic ovary syndrome: a systematic review and meta-analysis","Systematic review of interventions","11 March 2020","28 April 2020","2","FALSE","Registered","China",null],["CRD42020183541","retrieved","Comparative effects of oral pharmacotherapy interventions in improving pregnancy outcome of infertile women with polycystic ovary syndrome: a network meta-analysis","Systematic review of interventions","02 May 2020","05 July 2020","1","FALSE","Registered","China",null],["CRD42020188247","retrieved","Effects of GLP-1 on ovarian dysfunction in polycystic ovary syndrome: A protocol for systematic review and meta-analysis","Systematic review of interventions","25 May 2020","05 July 2020","1","FALSE","Registered","China",null],["CRD42020189464","retrieved","Glucose-lowering medications and fracture risks: an updated systematic review and meta-analysis","Systematic review of interventions","31 May 2020","05 July 2020","3","FALSE","Registered","China",null],["CRD42020193692","retrieved","Phenotypes of diabetes associated with COVID-19 severity and mortality: a living systematic review and meta-analysis","Systematic review of interventions","22 June 2020","22 June 2020","4","FALSE","Registered","Germany",null],["CRD42020195869","retrieved","Efficacy and Safety of Incretin-based Therapies for Weight Loss in Children and Adolescents with Obesity","Systematic review of interventions","28 June 2020","30 July 2020","2","FALSE","Registered","Canada, Ireland, United States of America",null],["CRD42020199840","retrieved","Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","31 July 2020","31 August 2020","1","FALSE","Registered","China",null],["CRD42020201507","retrieved","Bariatric Surgery, sodium-glucose cotransporter protein-2 inhibitors, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, and insulin for type 2 Diabetes and obesity: A Bayesian Network Meta-Analysis of randomized controlled trials","Systematic review of interventions","29 July 2020","28 August 2020","5","FALSE","Registered","Hong Kong",null],["CRD42020206600","retrieved","SGLT2 inhibitors on cardiovascular outcome - a meta-analysis of randomized controlled trials","Systematic review of interventions","28 August 2020","28 September 2020","1","FALSE","Registered","Taiwan",null],["CRD42020208090","retrieved","Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With Kidney Outcomes in Patients With Type 2 Diabetes: A Systematic Review and Network Meta-analysis","Systematic review of interventions","20 September 2020","21 October 2020","1","FALSE","Registered","China",null],["CRD42020212025","retrieved","Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-analysis","Systematic review of interventions","30 September 2020","30 October 2020","1","FALSE","Registered","China",null],["CRD42020212994","retrieved","Comparison of different kinds of hypoglycemic drugs on the risk of atrial fibrillation in diabetic patients","Systematic review of interventions","06 October 2020","05 November 2020","1","FALSE","Registered","China",null],["CRD42020213127","retrieved","Oral antidiabetic medications (OAD) vs Optimized Standard Therapy (TPO) and Hospitalisation for Heart Failure (HHF) in patients with type 2 diabetes (T2DM): Network Meta-analysis","Systematic review of interventions","08 October 2020","08 November 2020","1","FALSE","Registered","Brazil",null],["CRD42020221951","retrieved","The association between hypoglycemic agents and clinical outcomes of COVID-19 in patients with diabetes: a systematic review and meta-analysis","Systematic review of interventions","21 November 2020","24 November 2020","3","FALSE","Registered","China, United States of America",null],["CRD42020223435","retrieved","GLP-1 and GIP receptor agonists in the treatment of Parkinson's disease: Translational systematic review and meta-analysis of clinical and preclinical studies","Systematic review of interventions","29 November 2020","30 November 2020","1","FALSE","Registered","Brazil",null],["CRD42021178888","retrieved","Meta-analysis of heterogeneous studies regarding liraglutide add-on therapy for type 2 diabetes mellitus patients treated with insulin.","Systematic review of interventions","14 March 2021","13 April 2021","3","FALSE","Registered","Japan",null],["CRD42021226231","retrieved","The cardiac effect of GLP-1 receptor agonists on patients with heart failure.","Systematic review of interventions","14 December 2020","14 January 2021","2","FALSE","Registered","China",null],["CRD42021226307","retrieved","Systemic medications and dementia risk: umbrella review of systematic reviews and meta-analyses","Systematic review of interventions","06 January 2021","01 February 2021","1","FALSE","Registered","England",null],["CRD42021228824","retrieved","Meta-analysis of the effects of glucagon-like peptide 1 receptor agonists in non-alcoholic fatty liver disease patients with type 2 diabetes","Systematic review of interventions","04 January 2021","04 February 2021","1","FALSE","Registered","India",null],["CRD42021245678","retrieved","Pharmacotherapy for overweight or obese adults: a network meta-analysis of randomized controlled trials","Systematic review of interventions","29 March 2021","28 April 2021","2","FALSE","Registered","China",null],["CRD42021247584","retrieved","Comparative effect of sodium-glucose-linked cotransporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists on body weight and clinical outcomes in patients with type 2 diabetes: a meta-analysis","Systematic review of interventions","07 April 2021","05 May 2021","1","FALSE","Registered","China",null],["CRD42021248314","retrieved","The Effect of Oral Antidiabetic Drugs for Improving the Endocrine and Metabolic Profile in Women with Polycystic Ovary Syndrome: A Systematic Review and Network Meta-analysis","Systematic review of interventions","11 April 2021","12 May 2021","2","FALSE","Registered","China",null],["CRD42021251704","retrieved","Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for Insulin resistance in Non-alcoholic Fatty Liver Disease: systematic review and network meta-analysis of randomised controlled trials","Systematic review of interventions","27 April 2021","25 May 2021","3","FALSE","Registered","China",null],["CRD42021252381","retrieved","Post-Deep Brain Stimulation Psychosis in Parkinson’s Disease – A systematic review and meta-analysis","Systematic review of interventions","30 April 2021","31 May 2021","2","FALSE","Registered","Taiwan",null],["CRD42021256363","retrieved","Comparison of Diabetes Treatments in Patients with Glycemic Variability Diabetes: A Network Meta-analysis.","Systematic review of interventions","25 May 2021","25 June 2021","5","FALSE","Registered","South Korea",null],["CRD42021257670","retrieved","A systematic review and Meta-analysis: cotadutide vs placebo in type 2 Diabetes Mellitus","Systematic review of interventions","27 May 2021","27 June 2021","2","FALSE","Registered","Egypt",null],["CRD42021258103","retrieved","Efficacy and safety of SGLT‑2 inhibitors versus GLP-1 receptor agonists in overweight/obese patients wih or without diabetes mellitus: a systematic review and network meta-analysis","Systematic review of interventions","31 May 2021","29 June 2021","3","FALSE","Registered","China",null],["CRD42021259336","retrieved","New generation of Anti-Diabetic Agents in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD): A systematic review and network meta-analysis of randomized controlled trials.","Systematic review of interventions","05 June 2021","06 July 2021","2","FALSE","Registered","Thailand",null],["CRD42021259661","retrieved","Effects of glucagon-like peptide-1 receptor agonist (GLP-1RA) on Cardiac Structure and Function: A systematic review and meta-analysis of randomized-controlled trials","Systematic review of interventions","08 June 2021","09 July 2021","3","FALSE","Registered","Singapore",null],["CRD42021259711","retrieved","Cardiovascular, mortality and renal outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials","Systematic review of interventions","07 June 2021","09 June 2021","4","FALSE","Registered","Canada, Denmark, Italy, Scotland, Singapore, United States of America",null],["CRD42021260040","retrieved","Glucagon-like peptide-1 receptor agonists and cardioprotective benefit in patients with type 2 diabetes without baseline metformin: An update meta-analysis","Systematic review of interventions","09 June 2021","09 July 2021","2","FALSE","Registered","Argentina",null],["CRD42021260167","retrieved","Effects of new antidiabetic agents on cardiovascular outcomes in older adults: systemic review and meta-analysis","Systematic review of interventions","16 July 2021","16 August 2021","3","FALSE","Registered","United States of America",null],["CRD42021265806","retrieved","Efficacy and safety of Glucagon-Like Peptide-1 (GLP-1) receptor agonists in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review and meta-analysis","Systematic review of interventions","04 July 2021","02 August 2021","1","FALSE","Registered","China",null],["CRD42021268563","retrieved","Cardiovascular outcomes of diabetic medications used in chronic kidney disease patients","Systematic review of interventions","18 July 2021","29 July 2021","3","FALSE","Registered","Scotland",null],["CRD42021271599","retrieved","Gallbladder or biliary diseases and glucagon-like peptide 1 receptor agonists: a systematic review and meta-analysis","Systematic review of interventions","03 August 2021","03 September 2021","3","FALSE","Registered","China",null],["CRD420212716429","not found",null,null,null,null,null,null,null,null,null],["CRD42021271647","retrieved","Gallbladder or biliary diseases and dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis","Systematic review of interventions","03 August 2021","03 September 2021","2","FALSE","Registered","China",null],["CRD42021282668","retrieved","Lipid profile changes by dipeptidyl peptidase-4 inhibitor and gut hormone-based therapy in patients with type 2 diabetes: a systematic review and network meta-analysis","Systematic review of interventions","30 September 2021","22 November 2021","3","FALSE","Registered","South Korea",null],["CRD42021283129","retrieved","Potential use of off-label therapy for NAFLD with or without Diabetes Mellitus:systematic review and network meta-analysis of randomised controlled trials","Systematic review of interventions","08 October 2021","08 November 2021","2","FALSE","Registered","China",null],["CRD42021283449","retrieved","Tirzepatide for type 2 diabetes. Systematic review and meta-analysis","Systematic review of interventions","07 October 2021","08 November 2021","3","FALSE","Registered","Greece",null],["CRD42021284897","retrieved","Comparative Efficacy and Safety of Hypoglycemic Drugs in Children and Adolescents With Type 2 Diabetes: A Systematic Review and Network Meta-analysis","Systematic review of interventions","15 October 2021","15 November 2021","2","FALSE","Registered","China",null],["CRD42021287205","retrieved","Network Meta-Analysis on pharmacological interventions in non-alcoholic steatohepatitis","Systematic review of interventions","24 October 2021","29 November 2021","1","FALSE","Registered","Italy",null],["CRD42021288200","retrieved","The association between anti-diabetic agents and clinical outcomes of COVID-19 patients with diabetes: a systematic review and Bayesian network meta-analysis","Systematic review of interventions","29 October 2021","29 October 2021","1","FALSE","Registered","China",null],["CRD42021289121","retrieved","Glucagon‐like peptide‐1 receptor agonists and the risk of thyroid diseases: a systematic review and meta-analysis","Systematic review of interventions","03 November 2021","03 December 2021","2","FALSE","Registered","China",null],["CRD42022299690","retrieved","Difference in Treatment Effect Size between Cardiovascular and Renal outcomes in Kidney Disease and Type 2 Diabetes Trials: A Meta-Epidemiologic Study","Systematic review of interventions","21 December 2021","21 January 2022","3","FALSE","Registered","France",null],["CRD42022302648","retrieved","Systematic review on the pharmacoeconomic evaluations of anti-obesity drugs for long-term use: a methodological appraisal","Systematic review of interventions","10 January 2022","10 February 2022","2","FALSE","Registered","China",null],["CRD42022302942","retrieved","Systematic review of clinical and cost-effectiveness of endoscopic treatments for obesity to inform a model-based cost-effectiveness analysis","Systematic review of interventions","11 January 2022","11 January 2022","1","FALSE","Registered","England",null],["CRD42022306164","retrieved","Real-world evidence of once-weekly semaglutide in type 2 diabetes Mellitus: a systematic review","Systematic review of interventions","21 January 2022","21 February 2022","2","FALSE","Registered","China",null],["CRD42022313002","retrieved","Effect of liraglutide on body composition among overweight and obese adult with type 2 diabetes : A systematic review","Systematic review of interventions","26 February 2022","29 March 2022","2","FALSE","Registered","Saudi Arabia",null],["CRD42022319442","retrieved","Efficacy and Safety of Tirzepatide in Patients with Type 2 Diabetes Mellitus: A systematic review and meta-analysis","Systematic review of interventions","21 March 2022","21 April 2022","3","FALSE","Registered","China",null],["CRD42022320157","retrieved","Effects of GLP1 receptor analogs on cardiovascular outcomes in patients with chronic kidney disease: a systematic review and meta-analysis.","Systematic review of interventions","25 March 2022","25 April 2022","2","FALSE","Registered","United States of America",null],["CRD42022322129","retrieved","Anti-diabetic Medications Network Meta-analysis","Systematic review of interventions","30 March 2022","30 April 2022","4","FALSE","Registered","United States of America",null],["CRD42022325948","retrieved","Antihyperglycaemic drugs and nonsteroidal MRAs in adults living with type 2 diabetes: a living systematic review and network meta-analysis","Systematic review of interventions","09 May 2022","20 May 2022","3","FALSE","Registered","Canada, China, Germany, New Zealand, Norway, Sweden, United States of America",null],["CRD42022326382","retrieved","Effect of new glucose-lowering drugs on stroke in patients with type 2 diabetes：A Systematic Review and Meta-analysis","Systematic review of interventions","25 May 2022","05 June 2022","4","FALSE","Registered","China",null],["CRD42022327974","retrieved","Systematic literature review on the time to basal insulin intensification in people living with type 2 diabetes","Systematic review of interventions","16 June 2022","21 June 2022","4","FALSE","Registered","Canada, England",null],["CRD42022329878","retrieved","Efficacy of tirzepatide compared to high dose GLP-1RA, SGLT-2I/GLP-1RA combination and fixed-dose GLP-1RA/insulin combination: a systematic review and network meta-analysis.","Systematic review of interventions","05 May 2022","16 May 2022","2","FALSE","Registered","Italy",null],["CRD42022330442","retrieved","A critical view over the newest antidiabetic molecules in light of efficacy – a meta-analysis","Systematic review of interventions","13 May 2022","24 May 2022","6","FALSE","Registered","Romania",null],["CRD42022331547","retrieved","Association of GLP-1 Receptor Agonist Use with Adverse Cerebrovascular Outcomes in Type 2 Diabetes Mellitus: A Meta-analysis of Randomized Controlled Trials","Systematic review of interventions","09 May 2022","20 May 2022","3","FALSE","Registered","India",null],["CRD42022332052","retrieved","The association between antidiabetic, antihypertensive, lipid-lowering drugs, and diabetic retinopathy in people with type 2 diabetes: an umbrella review protocol","Systematic review of interventions","12 May 2022","17 May 2022","1","FALSE","Registered","England",null],["CRD42022332339","retrieved","A systematic review of possible drug-drug interactions between glucagon-like peptide 1 receptor agonists and oral medications","Systematic review of interventions","12 May 2022","23 May 2022","4","FALSE","Registered","Israel",null],["CRD42022333040","retrieved","Effect of Glucagon-like peptide-1 receptor-agonists treatment on cardio-metabolic parameters in antipsychotic‐treated patients with schizophrenia: A Systematic Review and Meta-Analysis","Systematic review of interventions","17 May 2022","28 May 2022","2","FALSE","Registered","Egypt, Jordan, Sudan",null],["CRD42022335504","retrieved","Cardiovascular and Renal Outcomes of GLP-1 Receptor Agonists versus DPP-4 inhibitors and Basal insulin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Protocol","Systematic review of interventions","01 June 2022","12 June 2022","2","FALSE","Registered","Denmark",null],["CRD42022337099","retrieved","Efficacy and safety of subcutaneous semaglutide in overweight or obese people：a meta-analysis of randomised controlled trials","Systematic review of interventions","02 June 2022","13 June 2022","2","FALSE","Registered","China",null],["CRD42022337559","retrieved","GLP-1 receptor agonists, SGLT-2 inhibitors and non-cardiovascular death: A systematic review and meta-analysis","Systematic review of interventions","04 June 2022","15 June 2022","2","FALSE","Registered","India",null],["CRD42022339389","retrieved","Association of glucagon-like peptide-1 receptor agonists with cardiac arrhythmias in patients with type 2 diabetes or obesity: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","13 June 2022","23 June 2022","3","FALSE","Registered","China",null],["CRD42022341966","retrieved","Optimal Dose of Tirzepatide for Type 2 Diabetes Mellitus: A Meta-analysis and Trial Sequential Analysis","Systematic review of interventions","24 June 2022","05 July 2022","3","FALSE","Registered","China",null],["CRD42022342241","retrieved","Comparison of efficacy and safety of GLP-1 RA for the Treatment of Type 2 Diabetes Mellitus: A Network Meta-analysis","Systematic review of interventions","29 June 2022","09 July 2022","2","FALSE","Registered","China",null],["CRD42022342373","retrieved","Systematic review with Bayesian network meta- analysis: comparative efficacy of pharmacologic therapies for Nonalcoholic Fatty Liver Disease with Type 2 Diabetics","Systematic review of interventions","08 July 2022","18 July 2022","2","FALSE","Registered","China",null],["CRD42022342845","retrieved","Comparative Effectiveness of Tizepatide, Liraglutide, Semaglutide and other GLP-1 receptor agonists for type 2 diabetes: a systematic review with network meta-analysis","Systematic review of interventions","28 June 2022","09 July 2022","2","FALSE","Registered","China",null],["CRD42022343601","retrieved","Newly approved and promising drugs for T2DM patient with chronic kidney disease on improving kidney outcomes: a network meta-analysis of randomized controlled trials","Systematic review of interventions","17 September 2022","28 September 2022","3","FALSE","Registered","China",null],["CRD42022347233","retrieved","SGLT-2 Inhibitors and GLP-1 Agonists: First-Line Therapy for Diabetes, A Meta-Analysis","Systematic review of interventions","31 August 2022","10 September 2022","2","FALSE","Registered","China",null],["CRD42022347280","retrieved","Impact of antidiabetic agents on cognitive impairment risk among patients with type 2 diabetes: A Bayesian network meta-analysis","Systematic review of interventions","18 July 2022","29 July 2022","2","FALSE","Registered","China",null],["CRD42022347472","retrieved","Efficacy of Liraglutide in obesity in children and adolescents: systematic review and meta-analysis of randomized controlled trials.","Systematic review of interventions","18 July 2022","29 July 2022","5","FALSE","Registered","Peru",null],["CRD42022347901","retrieved","Risk factors Differences in Cardiovascular Outcomes with Glucose lowering drugs in Type 2 Diabetes: Meta-analyses of Results from Randomized Trials","Systematic review of interventions","20 July 2022","31 July 2022","2","FALSE","Registered","France",null],["CRD42022348576","retrieved","Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist Tirzepatide for the treatment of obesity: a systematic review and meta-analysis of Randomized Controlled Trials","Systematic review of interventions","24 July 2022","03 August 2022","5","FALSE","Registered","Brazil",null],["CRD42022349665","retrieved","The impact of bariatric surgery, lifestyle change and pharmacotherapy on fertility in men with obesity – a systematic review and meta-analysis protocol","Systematic review of interventions","28 July 2022","07 August 2022","5","FALSE","Registered","Australia",null],["CRD42022357886","retrieved","Clinical outcomes with GLP-1 receptor agonists in patients with heart failure: a meta-analysis of randomized trials.","Systematic review of interventions","08 September 2022","19 September 2022","2","FALSE","Registered","China",null],["CRD42022359346","retrieved","Risk of digestive tract reactions caused by GLP-1RA: a network meta-analysis","Systematic review of interventions","10 September 2022","21 September 2022","3","FALSE","Registered","China",null],["CRD42022367488","retrieved","The effect of weight-loss interventions on polycystic ovarian syndrome (PCOS): a systematic review of randomised controlled trials","Systematic review of interventions","14 October 2022","14 October 2022","2","FALSE","Registered","England",null],["CRD42022367633","retrieved","Effect of GLP-1 Receptor Agonists on Heart Failure and Mortality inType 2 Diabetes With or Without Prior Heart Failure: A Pooled Analysis","Systematic review of interventions","15 October 2022","25 October 2022","3","FALSE","Registered","India",null],["CRD42022371264","retrieved","GLP-1-ra and heart failure-related outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis.","Systematic review of interventions","29 October 2022","09 November 2022","2","FALSE","Registered","Italy, Sweden",null],["CRD42022371697","retrieved","Effectiveness and safety of liraglutide for weight loss failure after bariatric interventions - a systematic review","Systematic review of interventions","31 October 2022","10 November 2022","2","FALSE","Registered","Portugal",null],["CRD42022382165","retrieved","Pharmacological management of type 2 diabetes in children and adolescents: a systematic review and meta-analysis","Systematic review of interventions","07 December 2022","12 December 2022","5","FALSE","Registered","England, United States of America",null],["CRD42022382594","retrieved","Tirzepatide compared to once weekly semaglutide for type 2 diabetes: protocol for a systematic review and network meta-analysis.","Systematic review of interventions","08 December 2022","19 December 2022","3","FALSE","Registered","Greece",null],["CRD42023390735","retrieved","Glucagon-Like Peptide-1 Receptor Agonists for Inflammatory indicators and Fibrosis of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis：systematic review and meta-analysis","Systematic review of interventions","10 January 2023","21 January 2023","2","FALSE","Registered","China",null],["CRD42023393020","retrieved","Glucagon-like peptide-1 receptor agonists on serum lipid profile of children with type 2 diabetes mellitus: a systematic review and meta-analysis","Systematic review of interventions","23 January 2023","03 February 2023","3","FALSE","Registered","Brazil",null],["CRD42023396138","retrieved","A meta-analysis of glucagon-like peptide-1 receptor agonists and risk of respiratory disease","Systematic review of interventions","01 February 2023","12 February 2023","2","FALSE","Registered","China",null],["CRD42023398452","retrieved","Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonist (GLP-1RA) Among Patients with Type 2 Diabetes Mellitus (T2DM) and Advanced Chronic Kidney Disease (CKD): A systematic review and meta-analysis","Systematic review of interventions","10 February 2023","21 February 2023","3","FALSE","Registered","United States of America",null],["CRD42023400899","retrieved","Blood pressure-lowering effect of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes for preventing of cardiovascular events and death: a systematic review and meta-analysis","Systematic review of interventions","18 February 2023","01 March 2023","2","FALSE","Registered","France",null],["CRD42023401734","retrieved","Racial/ethnic differences in the effect of glucagon-like peptide 1 receptor agonists and sodium–glucose co-transporter 2 inhibitors on cardiovascular and renal outcomes: A meta-analysis of cardiovascular outcome trials","Systematic review of interventions","21 February 2023","21 February 2023","2","FALSE","Registered","England",null],["CRD42023403859","retrieved","Efficacy and Safety of Mazdutide on weight reduction among overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials.","Systematic review of interventions","14 March 2023","25 March 2023","2","FALSE","Registered","China, Libya, Nigeria, Portugal, Rwanda, South Africa, Tanzania, Zambia",null],["CRD42023404309","retrieved","A systematic review and meta-analysis of drug therapy in patients with non-alcoholic fatty liver diseases or non-alcoholic steatohepatitis","Systematic review of interventions","03 March 2023","14 March 2023","2","FALSE","Registered","China",null],["CRD42023405356","retrieved","Kidney outcomes in patients with type 2 diabetes treated with GLP-1 RA compared with other glucose-lowering agents in real-world settings - Systematic review and meta-analysis","Systematic review of interventions","05 March 2023","16 March 2023","2","FALSE","Registered","Israel",null],["CRD42023409585","retrieved","Efficacy and safety of IDegLira versus glucagon-like peptide-1 receptor agonists (GLP-1RA) plus basal insulin in Type 2 Diabetes Mellitus: A systematic review and network meta-analysis","Systematic review of interventions","21 March 2023","01 April 2023","0","FALSE","Registered","China",null],["CRD42023410345","retrieved","Treatment strategy selection for T2DM patients poorly treated with basal insulin combined with oral hypoglycemic agents: Umbrella Review","Systematic review of interventions","22 March 2023","02 April 2023","2","FALSE","Registered","China",null],["CRD42023412400","retrieved","Safety issues of Tirzepatide (pancreatitis and gallbladder or biliary disease) in type 2 diabetes and obesity: Systematic review and Meta-analysis","Systematic review of interventions","04 April 2023","15 April 2023","2","FALSE","Registered","China",null],["CRD42023413199","retrieved","Glucagon-like 1 receptor agonist and diabetic retinopathy risk in patients with type 2 diabetes: A meta-analysis of randomized placebo Trials","Systematic review of interventions","31 March 2023","11 April 2023","2","FALSE","Registered","China",null],["CRD42023418166","retrieved","Effects of glucagon-like peptide-1 receptor agonists on bone metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.","Systematic review of interventions","18 April 2023","28 April 2023","2","FALSE","Registered","China",null],["CRD42023418551","retrieved","Impact of a dual GIP/GLP-1 receptor agonist tirzepatide on heart rate among patients with type 2 diabetes: A systematic review and pairwise and Bayesian network meta-analysis","Systematic review of interventions","21 April 2023","02 May 2023","3","FALSE","Registered","China",null],["CRD42023420729","retrieved","Effect of sleep apnoea interventions on multiple health outcomes: umbrella review of meta-analyses of randomised controlled trials","Systematic review of interventions","23 April 2023","04 May 2023","0","FALSE","Registered","France",null],["CRD42023426190","retrieved","Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) Among Kidney Transplant Recipients: A systematic review and meta-analysis","Systematic review of interventions","12 May 2023","23 May 2023","5","FALSE","Registered","United States of America",null],["CRD42023429701","retrieved","Comparison of the efficacy and safety of hypoglycemic treatments in patients with non-alcoholic fatty liver disease and type 2 diabetes: A systematic review and Bayesian network analysis","Systematic review of interventions","25 May 2023","05 June 2023","2","FALSE","Registered","China",null],["CRD42023433123","retrieved","Pharmacological interventions for the treatment of obesity in children and adolescents","Systematic review of interventions","04 July 2023","05 July 2023","3","FALSE","Registered","England, Germany, Italy, United States of America",null],["CRD42023438624","retrieved","Glucagon-Like Peptide-1 Receptor (GLP-1) Agonist Use in the Perioperative Period with a focus on Gastric Emptying Effects: A Systematic Review","Systematic review of interventions","24 June 2023","04 July 2023","2","FALSE","Registered","United States of America",null],["CRD42023445927","retrieved","American Society of Regional Anesthesia and Pain Medicine recommendations on Gastric Ultrasound for assessing aspiration risk in complex patients undergoing regional and pain procedures","Systematic review of interventions","19 July 2023","31 July 2023","3","FALSE","Registered","Canada, United States of America",null],["CRD42023448720","retrieved","Risk of Bone Fracture by Using Dipeptidyl Peptidase-4 Inhibitors, Glucagon-like Peptide-1 Receptor Agonists, or Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Type 2 Diabetes Mellitus: A Network Meta-analysis of population-based cohort studies","Systematic review of interventions","12 September 2023","23 September 2023","2","FALSE","Registered","Saudi Arabia",null],["CRD42023449059","retrieved","Effect of glucagon-like peptide 1 receptor agonists on mortality, renal and cardiovascular outcomes in patients with chronic kidney disease: a systematic review and network meta-analysis","Systematic review of interventions","28 July 2023","08 August 2023","2","FALSE","Registered","Taiwan",null],["CRD42023450979","retrieved","Efficacy and Safety of Semaglutide in Overweight or Obese Adults with or without Type 2 Diabetes: A Systematic Review and Meta-Analysis","Systematic review of interventions","03 August 2023","14 August 2023","2","FALSE","Registered","China",null],["CRD42023458228","retrieved","Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists on Body Composition and Anthropometric Indices: A Systematic Review and Network Meta-Analysis","Systematic review of interventions","27 August 2023","07 September 2023","2","FALSE","Registered","Thailand",null],["CRD42023461665","retrieved","Gastric content and perioperative pulmonary aspiration in patients using glucagon-like peptide 1 (GLP1) agonists","Systematic review of interventions","08 September 2023","18 September 2023","3","FALSE","Registered","Canada",null],["CRD42023469941","retrieved","The use of novel anti-diabetic medications and site-specific cancer risk: A systematic review and network meta-analysis of observational studies","Systematic review of interventions","13 November 2023","24 November 2023","4","FALSE","Registered","United States of America",null],["CRD42023472186","retrieved","Effects of GLP-1 receptor agonist therapy on hepatic fibrosis in metabolic dysfunction-associated steatotic liver disease: a systematic review","Systematic review of interventions","08 November 2023","20 November 2023","4","FALSE","Registered","Canada",null],["CRD42023473528","retrieved","Effect of GLP-1 on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis","Systematic review of interventions","17 October 2023","28 October 2023","2","FALSE","Registered","China",null],["CRD42023473875","retrieved","Investigating therapeutic options for preventing/delaying Diabetes Mellitus in prediabetic patients - a systematic review and meta-analysis of randomized control trials","Systematic review of interventions","07 November 2023","20 November 2023","2","FALSE","Registered","Hungary",null],["CRD42023473991","retrieved","Efficacy and safety of glucagon like peptide-1 receptor agonists in post-bariatric surgery patients: A systematic review and meta-analysis","Systematic review of interventions","18 October 2023","29 October 2023","3","FALSE","Registered","India",null],["CRD42023475226","retrieved","Cardiovascular benefits of GLP-1 receptor agonists in patients who are obese or overweight: a meta-analysis of randomized controlled trials","Systematic review of interventions","22 October 2023","02 November 2023","2","FALSE","Registered","Brazil",null],["CRD42023476762","retrieved","Use of glucagon-like peptide-1 (GLP-1) receptor agonists and risk of gastrointestinal cancer: a systematic review and meta-analysis of randomized controlled trials.","Systematic review of interventions","27 October 2023","08 November 2023","2","FALSE","Registered","Italy",null],["CRD42023480167","retrieved","Gender differences in weight loss effect of GLP-1 receptor agonists: A systematic review and meta-analysis","Systematic review of interventions","06 November 2023","17 November 2023","2","FALSE","Registered","China",null],["CRD42023489588","retrieved","Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: a systematic review and meta-analysis","Systematic review of interventions","04 December 2023","15 December 2023","2","FALSE","Registered","China",null],["CRD42023491646","retrieved","Pharmacological Treatments in Adults with Overweight or Obesity","Systematic review of interventions","08 December 2023","19 December 2023","0","FALSE","Registered","Netherlands",null],["CRD42023493235","retrieved","Evaluating the Intervention Effects of Semaglutide on Obesity: An Umbrella Review of Systematic Reviews","Systematic review of interventions","13 December 2023","24 December 2023","2","FALSE","Registered","China",null],["CRD42024498538","retrieved","GLP-1 and Cardiovascular Outcomes in Obese Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","03 January 2024","15 January 2024","2","FALSE","Registered","Jordan",null],["CRD42024498939","retrieved","Cardiovascular effectiveness and safety of new classes of glucose-lowering agents, with and without baseline lipid lowering therapy in type 2 diabetes: A systematic meta-analysis of cardiovascular outcome trials","Systematic review of interventions","03 January 2024","04 January 2024","2","FALSE","Registered","England",null],["CRD42024499511","retrieved","The adverse effects with semaglutide. A systematic review with meta-analysis and Trial Sequential Analysis","Systematic review of interventions","05 January 2024","16 January 2024","0","FALSE","Registered","Denmark, Germany",null],["CRD42024500551","retrieved","Anti-inflammatory effect of semaglutide: Systematic review and updated meta-analysis.","Systematic review of interventions","08 January 2024","19 January 2024","2","FALSE","Registered","Argentina",null],["CRD42024505558","retrieved","Efficacy and Safety of GLP-1 Receptor Agonists and Co-Agonists for Weight Loss Among Patients without Diabetes: A Systematic Review of Randomized Controlled Trials","Systematic review of interventions","23 January 2024","03 February 2024","2","FALSE","Registered","Canada",null],["CRD42024507397","retrieved","New incretin therapy focused on cardiovascular diseases in diabetes mellitus - a systematic review","Systematic review of interventions","28 January 2024","08 February 2024","2","FALSE","Registered","Italy, Romania",null],["CRD42024507993","retrieved","Drug treatments for adults with overweight or obesity: a systematic review and network meta-analysis","Systematic review of interventions","11 March 2024","22 March 2024","2","FALSE","Registered","China",null],["CRD42024511198","retrieved","Pharmacological interventions in type 2 diabetes mellitus remission: a systematic mapping of clinical trial registries.","Systematic review of interventions","13 March 2024","24 March 2024","2","FALSE","Registered","France",null],["CRD42024511703","retrieved","Efficacy and safety of twincretin cotadutide a dual glucagon-like peptide 1 and glucagon receptor agonist as an anti-obesity and anti-diabetes medication: A systematic review and meta-analysis","Systematic review of interventions","10 February 2024","21 February 2024","0","FALSE","Registered","India",null],["CRD42024515966","retrieved","Risk of major adverse cardiovascular events and stroke under treatment with GLP-1 RAs or the dual GIP/GLP-1 receptor agonist tirzepatide in adults with overweight or obesity without diabetes: a systematic review and meta-analysis","Systematic review of interventions","20 February 2024","02 March 2024","2","FALSE","Registered","Greece",null],["CRD42024516313","retrieved","GLP-1 agonists and beta-cell exhaustion in diabetes mellitus treatment: systematic review and meta-analysis","Systematic review of interventions","06 March 2024","18 March 2024","2","FALSE","Registered","Grenada",null],["CRD42024518348","retrieved","Comparative Effectiveness and Safety of Sodium–Glucose Cotransporter 2 Inhibitors vs Glucagon-Like Peptide 1 Receptor Agonists in Older Adults: a meta-analysis","Systematic review of interventions","27 February 2024","09 March 2024","2","FALSE","Registered","China",null],["CRD42024519474","retrieved","Effects of diffenrent hypoglycemic agents in reducing carotid intima-media thickness: a network meta-analysis in patients","Systematic review of interventions","01 March 2024","12 March 2024","2","FALSE","Registered","China",null],["CRD42024522782","retrieved","Effect of glucagon-like peptide-1 receptor agonists in arthritis: A systematic review","Systematic review of interventions","10 March 2024","21 March 2024","2","FALSE","Registered","Australia",null],["CRD42024522787","retrieved","Effect of glucagon-like peptide-1 receptor agonists in arthritis pre-clinical studies: A systematic review","Systematic review of interventions","10 March 2024","23 April 2024","1","FALSE","Registered","Australia",null],["CRD42024528864","retrieved","The effects of glucagon-like peptide-1 receptor agonists on kidney and cardiovascular outcomes in type 2 diabetes: A systematic review and meta-analysis of randomised controlled trials","Systematic review of interventions","26 March 2024","06 April 2024","4","FALSE","Registered","Australia",null],["CRD42024531982","retrieved","Does glucagon-like peptide 1 analogue reduce alcohol intake in people with alcohol use disorder: a systematic review","Systematic review of interventions","03 April 2024","03 April 2024","1","FALSE","Registered","England",null],["CRD42024532368","retrieved","Efficacy and Safety of Incretin-Based Dual and Triple Agonists in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis","Systematic review of interventions","30 June 2024","10 July 2024","2","FALSE","Registered","Australia",null],["CRD42024532383","retrieved","Combining sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a systematic review and meta-analysis","Systematic review of interventions","20 May 2024","31 May 2024","2","FALSE","Registered","Netherlands",null],["CRD42024532600","retrieved","Comparative efficacy of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, thiazolidinediones and vitamin E for nonalcoholic fatty liver disease: a Bayesian network meta-analysis","Systematic review of interventions","05 April 2024","17 April 2024","2","FALSE","Registered","China",null],["CRD42024532845","retrieved","GLP-1 receptor agonists’ efficacy, safety and effects on metabolic parameters in pediatric patients with obesity: A systematic review and meta-analysis","Systematic review of interventions","05 April 2024","17 April 2024","0","FALSE","Registered","Brazil",null],["CRD42024535096","retrieved","Pharmacological treatment of polycystic ovary syndrome- short- and long-term effects on health and quality of life","Systematic review of interventions","02 May 2024","13 May 2024","2","FALSE","Registered","Sweden",null],["CRD42024537006","retrieved","Evaluation and comparison of efficacy and safety of tirzepatide，liraglutide and SGLT2i in patients with type2 diabetes mellitus: A Bayesian network meta-analysis","Systematic review of interventions","17 April 2024","29 April 2024","2","FALSE","Registered","China",null],["CRD42024538789","retrieved","Effect of Anti-Diabetic Treatment on Bone health in Type 2 Diabetes: A Meta-Analysis","Systematic review of interventions","22 April 2024","03 May 2024","2","FALSE","Registered","South Korea",null],["CRD42024538847","retrieved","Semaglutide and Cardiovascular Outcomes; A Systematic Review and Meta-analysis","Systematic review of interventions","02 May 2024","13 May 2024","2","FALSE","Registered","Iran",null],["CRD42024539634","retrieved","The efficacy and safety of GLP-1 receptor agonists for weight loss in overweight/obesity persons with or without type 2 diabetes : A systematic review and network meta-analysis","Systematic review of interventions","24 April 2024","05 May 2024","2","FALSE","Registered","Thailand",null],["CRD42024542379","retrieved","Comparative Effectiveness of Antidiabetic Drugs in Obstructive Lung Diseases in Type 2 Diabetes","Systematic review of interventions","01 May 2024","13 May 2024","4","FALSE","Registered","China",null],["CRD42024543945","retrieved","Glucagon-like peptide-1 receptor agonist for prevention of digestive system neoplasms in adult patients with diabetes or obesity: a systematic review and network meta-analysis","Systematic review of interventions","06 May 2024","17 May 2024","2","FALSE","Registered","China",null],["CRD42024546896","retrieved","Glucagon-like peptide-1 receptor agonists and psychiatric diseases: a systematic review and meta-analysis","Systematic review of interventions","21 May 2024","01 June 2024","2","FALSE","Registered","China",null],["CRD42024547905","retrieved","A Meta-Analysis Comparing pharmacotherapy for obesity and overweight: Efficacy, Safety, Cardiometabolic and Psychological Impact","Systematic review of interventions","17 May 2024","27 May 2024","2","FALSE","Registered","China",null],["CRD42024553048","retrieved","Comparison of glucagon-like peptide-1 receptor agonists vs placebo on any cardiovascular events in overweight or obese non-diabetic patients: A systematic review and meta-analysis","Systematic review of interventions","31 May 2024","10 June 2024","2","FALSE","Registered","Nepal",null],["CRD42024554005","retrieved","Comparative efficacy and safety of multi-receptor antidiabetic drugs: a systematic review and network meta-analysis","Systematic review of interventions","03 June 2024","15 June 2024","2","FALSE","Registered","China",null],["CRD42024556732","retrieved","Risk of aspiration and retained gastric contents with the Use of Glucagon-like Peptide-1 Receptor Agonists in endoscopy","Systematic review of interventions","10 June 2024","21 June 2024","4","FALSE","Registered","United States of America",null],["CRD42024558287","retrieved","Glucagon-like Peptide-1 Receptor Agonists for Obstructive Sleep Apnea in Patients with Obesity and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis","Systematic review of interventions","14 June 2024","25 June 2024","2","FALSE","Registered","China",null],["CRD42024562853","retrieved","Glucagon-like peptide-1 receptor agonist for the treatment of obstructive sleep apnea: A systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","27 June 2024","07 July 2024","2","FALSE","Registered","Jordan",null],["CRD42024564018","retrieved","GLP-1 Receptor Agonists for Obstructive Sleep Apnea: A Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","04 July 2024","14 July 2024","2","FALSE","Registered","Brazil, Chile, Singapore, Spain, United States of America",null],["CRD42024565439","retrieved","GLP1 Receptor Agonists and SGLT2 Inhibitors for the Prevention or Delay of Type 2 Diabetes Mellitus Onset","Systematic review of interventions","04 July 2024","16 July 2024","0","FALSE","Registered","Lebanon","N/A N/A"],["CRD42024565567","retrieved","Effect of Glucagon-like peptide 1 receptor agonists on peripheral arterial disease: A systematic review and meta-analysis of randomized clinical trials.","Systematic review of interventions","04 July 2024","16 July 2024","2","FALSE","Registered","Argentina",null],["CRD42024565765","retrieved","Effects of GLP-1 receptor agonists on clinical outcomes in type 2 diabetes with and without SGLT2 inhibitors: A systematic review and meta-analysis","Systematic review of interventions","05 July 2024","16 July 2024","3","FALSE","Registered","Australia",null],["CRD42024566153","retrieved","Efficacy and Safety of Triple Hormone Receptor Agonist Retatrutide for Obesity: A Systematic Review and Meta-Analysis","Systematic review of interventions","06 July 2024","16 July 2024","3","FALSE","Registered","India",null],["CRD42024566217","retrieved","The Anti-depressive effects of Glucagon-Like Peptide-1 Receptor Agonists: A Systematic Review and Meta-Analysis","Systematic review of interventions","10 July 2024","21 July 2024","2","FALSE","Registered","Taiwan",null],["CRD42024567890","retrieved","Safety and Efficacy of Naltrexone in the Treatment of Chronic Pain among Women: A Meta-Analysis and Systematic Review","Systematic review of interventions","11 July 2024","21 July 2024","2","FALSE","Registered","Saudi Arabia",null],["CRD42024570467","retrieved","FINE-HEART: An Integrated Pooled Analysis of Finerenone across 3 Phase III Trials of Heart Failure and Chronic Kidney Disease and Type 2 Diabetes","Systematic review of interventions","18 July 2024","28 July 2024","4","FALSE","Registered","United States of America",null],["CRD42024570728","retrieved","A systematic review of randomised controlled trials of weight loss drug treatments and binge eating disorder and related symptoms","Systematic review of interventions","18 July 2024","19 July 2024","1","FALSE","Registered","England",null],["CRD42024571356","retrieved","The Role of GLP-1 Agonists in Substance Use Disorders: A Comprehensive Systematic Review and Network Meta-Analysis","Systematic review of interventions","23 July 2024","03 August 2024","4","FALSE","Registered","United States of America",null],["CRD42024571544","retrieved","Clinical efficacy and safety of SGLT-2i, GLP-1 RA, and non-steroidal selective corticosteroid receptor antagonists (finerenone) in Type 2 diabetes mellitus with chronic kidney disease：A Network Meta Analysis of Randomised Clinical Trials","Systematic review of interventions","23 July 2024","02 August 2024","2","FALSE","Registered","China",null],["CRD42024573542","retrieved","Effects of weight control interventions on cardiovascular outcomes: an umbrella review of systematic reviews and meta-analyses","Systematic review of interventions","26 July 2024","06 August 2024","2","FALSE","Registered","China",null],["CRD42024576314","retrieved","The safety of tirzepatide, semaglutide and liraglutide for weight loss in patient with obesity and overweight: an systematic review and network meta-analysis of randomised controlled trials","Systematic review of interventions","04 August 2024","16 August 2024","2","FALSE","Registered","China",null],["CRD42024580784","retrieved","Cardiovascular safety profile with semaglutide and variations with gender, race and kidney function: A systematic review and meta-analysis","Systematic review of interventions","18 August 2024","28 August 2024","2","FALSE","Registered","Pakistan",null],["CRD42024582164","retrieved","Efficacy and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: a systematic review and meta-analysis","Systematic review of interventions","24 August 2024","03 September 2024","2","FALSE","Registered","China",null],["CRD42024585971","retrieved","GLP 1 RECEPTOR AGONISTS ASSOCIATED BOWEL OBSTRUCTION AND ILLEUS: A SYSTEMATIC REVIEW AND META-ANALYSIS","Systematic review of interventions","02 September 2024","13 September 2024","2","FALSE","Registered","Saudi Arabia",null],["CRD42024586000","retrieved","Glucagon-Like Peptide-1 Receptor Agonists’ Impact on Exosomal and Non-Exosomal microRNA Signatures in Management of Type 2 Diabetes Mellitus: A Systematic Review","Systematic review of interventions","02 September 2024","05 December 2024","0","FALSE","Registered","China, Iran",null],["CRD42024592308","retrieved","Comparative Gastrointestinal Adverse Effects of GLP-1 Receptor Agonists in Type 2 Diabetes: A Bayesian Network Meta-Analysis","Systematic review of interventions","19 September 2024","30 September 2024","2","FALSE","Registered","China",null],["CRD42024592825","retrieved","Comparison of the effectiveness of Tirzepatide, Semaglutide, Dulaglutide and Lixisenatide on major cardiovascular events and renal function in patients with type 2 diabetes: A network meta-analysis","Systematic review of interventions","21 September 2024","01 October 2024","0","FALSE","Registered","Vietnam","n/a n/a"],["CRD42024595241","retrieved","Role of GLP1 agonists on Pulmonary aspiration, gastric emptying, nausea, vomiting","Systematic review of interventions","27 September 2024","09 October 2024","2","FALSE","Registered","United States of America",null],["CRD42024599035","retrieved","The adverse effects with tirzepatide. A protocol for a systematic review with meta-analysis and Trial Sequential Analysis","Systematic review of interventions","11 October 2024","21 October 2024","0","FALSE","Registered","Denmark","Sillassen CDB, Petersen JJ, Kamp CB, et al Adverse effects with tirzepatide: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis BMJ Open 2025;15:e094947. doi: 10.1136/bmjopen-2024-094947 DOI: 10.1136/bmjopen-2024-094947"],["CRD42024599597","retrieved","Efficacy and Safety of Phramacological and Non-pharmacological Interventions on Weight Reduction in Anti-psychotic Induced Weight Gain: A Systematic Review and Network Meta-Analysis","Systematic review of interventions","26 October 2024","06 November 2024","2","FALSE","Registered","Egypt",null],["CRD42024599675","retrieved","GLP-1 and Obstructive Sleep Apnea (OSA): Efficacy of GLP-1 Receptor Agonists in Patients with Obesity or Diabetes and OSA—A Systematic Review and Meta-Analysis","Systematic review of interventions","10 October 2024","21 October 2024","2","FALSE","Registered","China",null],["CRD42024600250","retrieved","Efficacy of GLP-1 receptor agonists combined with lifestyle modification for the treatment of overweight and obesity: systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","11 October 2024","22 October 2024","2","FALSE","Registered","China",null],["CRD42024601021","retrieved","Comparative Efficacy and Safety of GLP-1 Receptor Agonists and SGLT2 Inhibitors in Mentality Status Change: A Network Meta-Analysis","Systematic review of interventions","13 October 2024","25 October 2024","2","FALSE","Registered","Taiwan",null],["CRD42024603661","retrieved","The efficacy and safety of glucagon-like peptide-1 receptor agonists in non-diabetic adults with overweight/obesity: an umbrella review of systematic reviews and meta-analyses","Systematic review of interventions","19 October 2024","30 October 2024","2","FALSE","Registered","Iran",null],["CRD42024605727","retrieved","Clinical Outcomes of Combined SGLT2 Inhibitors and GLP-1 Receptor Agonists versus Monotherapy: A Network Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","24 October 2024","04 November 2024","0","FALSE","Registered","Taiwan",null],["CRD42024606997","retrieved","Benefits and harms of glucagon-like peptide-1 receptor agonists in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","29 October 2024","10 November 2024","2","FALSE","Registered","Cyprus, Italy",null],["CRD42024608365","retrieved","Glucagon-Like Peptide-1 Receptor Agonists and the risk of cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","30 October 2024","10 November 2024","3","FALSE","Registered","United States of America",null],["CRD42024608736","retrieved","Efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) in polycystic ovarian syndrome: A meta-analysis with trial sequential analysis","Systematic review of interventions","23 November 2024","05 December 2024","0","FALSE","Registered","Saudi Arabia",null],["CRD42024609736","retrieved","Comparative Efficacy and Safety of GLP-1RA, Tirzepatide, and SGLT-2 Inhibitors in Metabolic Liver Disease: A Network Meta-Analysis","Systematic review of interventions","20 November 2024","30 November 2024","2","FALSE","Registered","Canada, Croatia, Greece, Singapore",null],["CRD42024613545","retrieved","Improvement of Irritable Bowel Syndrome with GLP-1 Receptor Agonists: A systematic Review and Meta-analysis","Systematic review of interventions","12 November 2024","23 November 2024","2","FALSE","Registered","Saudi Arabia",null],["CRD42024614466","retrieved","Effect of tirzepatide on the risk of developing type 2 diabetes mellitus among the people living with obesity or overweight: A systematic review and meta-analysis","Systematic review of interventions","15 November 2024","26 November 2024","0","FALSE","Registered","India",null],["CRD42024615851","retrieved","Incretin Therapies in Binge Eating Disorder","Systematic review of interventions","18 November 2024","29 November 2024","2","FALSE","Registered","United States of America",null],["CRD42024618146","retrieved","Effect of semaglutide on arrhythmic outcomes, major cardiovascular outcomes, and microvascular outcomes in patients with type 2 diabetes mellitus: a systematic review and meta-analysis","Systematic review of interventions","24 November 2024","05 December 2024","2","FALSE","Registered","China",null],["CRD42024620051","retrieved","Effect of tirzepatide on heart failure:a systematic review and meta-analysis","Systematic review of interventions","28 November 2024","10 December 2024","2","FALSE","Registered","China",null],["CRD42024623312","retrieved","The effects of glucagon-like peptide-1 analogues on hard binary outcomes for patients at increased risk of cardiovascular events: A systematic review with network meta-analysis and Trial Sequential Analysis","Systematic review of interventions","18 December 2024","29 December 2024","0","FALSE","Registered","Denmark","Sillassen CDB, Faltermeier P, Petersen JJ, et al Effects of glucagon-like peptide-1 analogues on hard binary outcomes for patients at increased risk of cardiovascular events: a protocol for a systematic review with network meta-analysis and Trial Sequential Analysis. BMJ Open 2025;15:e098205. doi: 10.1136/bmjopen-2024-098205 10.1136/bmjopen-2024-098205"],["CRD42024623707","retrieved","Obesity and overweight: efficacy and safety of EMA- and FDA-approved surgical, endoscopic, and pharmacological treatments. a comprehensive metanalysis and network metanalysis of randomized controlled trials.","Systematic review of interventions","07 December 2024","18 December 2024","2","FALSE","Registered","Italy",null],["CRD42024625338","retrieved","Development of the European Association for the Study of Obesity (EASO) Grade-Based Guidelines on the Pharmacological Treatment of Obesity: meta-analysis and network meta-analysis of randomized control trials on EMA-approved obesity management medications.","Systematic review of interventions","09 December 2024","20 December 2024","2","FALSE","Registered","Italy",null],["CRD42024626613","retrieved","Effects of Novel Antidiabetic Agents on Asthma-COPD Overlap Syndrome","Systematic review of interventions","12 December 2024","22 December 2024","0","FALSE","Registered","Taiwan",null],["CRD420250631751","retrieved","Weight Regain Following Cessation of GLP-1 Receptor Agonist Treatment in Overweight and Obese Adults: A Systematic Review and Meta-Analysis","Systematic review of interventions","30 January 2025","24 February 2025","0","FALSE","Registered","England",null],["CRD420250654193","retrieved","Glucagon-like peptide-1 (GLP-1) analogues for adult people with obesity: protocol for asystematic review with meta-analysis","Systematic review of interventions","19 February 2025","24 February 2025","0","FALSE","Registered","Chile",null],["CRD420250656321","retrieved","Emerging Therapeutic Potential of Glucagon-Like Peptide-1 Receptor Agonists in Knee Osteoarthritis: A Systematic Review","Systematic review of interventions","23 February 2025","24 February 2025","0","FALSE","Registered","China",null],["CRD420251002447","retrieved","Effect of glucagon-like peptide 1 receptor agonists on body composition","Systematic review of interventions","05 March 2025","06 March 2025","0","FALSE","Registered","Poland","A full protocol has been written but is not available because: It will be published as a part of the further publication"],["CRD420251003016","retrieved","Risk of Gynecologic Tumor Related to GLP-1 Receptor Agonists And SGLT2 Inhibitors Use","Systematic review of interventions","02 March 2025","02 March 2025","0","FALSE","Registered","Taiwan, Province of China","A full protocol has been written but is not available because: Based on personal reason to avoid plagiarism"],["CRD420251003374","retrieved","Cardiovascular Effects of Incretin-Based Drugs in Patients With and Without a History of Heart Failure: A Protocol for a Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials","Systematic review of interventions","14 April 2025","22 April 2025","0","FALSE","Registered","Denmark","A full protocol has been written but is not available because: The full protocol will be submitted soon."],["CRD420251007431","retrieved","SGLT-2 Inhibitors and semaglutide in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction","Systematic review of interventions","09 March 2025","28 April 2025","0","FALSE","Registered","Guinea ; France","A full protocol has not been written."],["CRD420251007882","retrieved","Association Between GLP-1 Receptor Agonists and Diabetic Retinopathy Progression: A Systematic Review and Meta-Analysis","Systematic review of interventions","09 April 2025","10 April 2025","0","FALSE","Registered","China ; Pakistan","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD42025100858","not found",null,null,null,null,null,null,null,null,null],["CRD420251008614","retrieved","GLP-1 receptor agonists for idiopathic intracranial hypertension (IIH): Systematic review and meta-analysis","Systematic review of interventions","11 March 2025","11 March 2025","0","FALSE","Registered","Egypt ; Palestine, State of ; United States of America","A full protocol has been written but is not available because: The protocol is not published yet ."],["CRD420251008703","retrieved","Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists in Parkinson's disease: a systematic review and meta-analysis","Systematic review of interventions","10 March 2025","12 March 2025","0","FALSE","Registered","Greece","A full protocol has not been written."],["CRD420251008819","retrieved","Comparative cardiovascular safety of subcutaneously tirzepatide and semaglutide for type 2 diabetes or obesity: a systematic review and meta-analysis","Systematic review of interventions","29 March 2025","29 March 2025","0","FALSE","Registered","China","A full protocol has been written and published. The protocol may be accessed here: Joseph L. Mathew. Systematic Reviews and Meta-Analysis: A Guide for Beginners. Indian Pediatrics. 2021 : 59 (4) : 320 -330 . doi: 10.1007/s13312-022-2500-y"],["CRD420251009075","retrieved","Effects of Glucagon-Like Peptide-1 Receptor Agonist on Alcohol Consumption: A Systematic Review and Meta-Analysis","Systematic review of interventions","11 March 2025","19 March 2025","0","FALSE","Registered","United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251009368","retrieved","Comparative Efficacy and Safety of GLP-1 Receptor Agonists and Co-Agonists for Weight Loss Among Patients without Diabetes: A Network Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","11 March 2025","11 March 2025","0","FALSE","Registered","Canada","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/e347ba20ead50955ce8823f4c7c319af.pdf ."],["CRD420251014401","retrieved","Analysis of the efficacy and safety profile of semaglutide, liraglutide and tirzepatide in the therapy of overweight and obesity: a systematic review and network meta-analysis","Systematic review of interventions","19 March 2025","18 November 2025","0","FALSE","Registered","Poland","A full protocol has been written but is not available because: The full protocol will be included in the publication"],["CRD420251015882","retrieved","The Role of GLP-1 Receptor Agonists in Surgery and Complications of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis","Systematic review of interventions","24 March 2025","24 March 2025","0","FALSE","Registered","Australia","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251016726","retrieved","Equivalence of weight-loss effects of Tirzepatide versus Sleeve Gastrectomy: A network meta-analysis and systematic review","Systematic review of interventions","26 March 2025","26 March 2025","0","FALSE","Registered","United Kingdom","A full protocol has not been written."],["CRD420251017953","retrieved","The efficacy of s.c. vs p.o. semaglutide in treatment of type 2 diabetes and its metabolic outcomes.","Systematic review of interventions","24 March 2025","24 March 2025","0","FALSE","Registered","Poland","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251019235","retrieved","Safety and Efficacy of Semaglutide in Patients with Chronic Kidney Disease, With or Without Type 2 Diabetes: A Systematic Review and Meta-Analysis","Systematic review of interventions","25 March 2025","06 April 2025","0","FALSE","Registered","Pakistan","A full protocol has been written but is not available because: A full protocol has not been developed as this systematic review follows established guidelines, including PRISMA and AMSTAR. However, the methodology, including search strategy, inclusion/exclusion criteria, data extraction, risk of bias assessment, and statistical analysis, has been pre-specified."],["CRD420251024082","retrieved","GLP-1 Receptor Agonists and musculoskeletal outcomes: an ESCEO systematic literature review and meta-analysis","Systematic review of interventions","01 April 2025","25 August 2025","0","FALSE","Registered","Belgium ; Saudi Arabia ; Finland","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251025534","retrieved","Effect of glucagon-like-peptide-1 receptor agonist (GLP-1 RA) therapy on neuropsychiatric outcomes: a systematic review","Systematic review of interventions","03 April 2025","24 April 2025","0","FALSE","Registered","United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251027809","retrieved","Evaluation of safety of preoperative GLP-1 receptor agonists in patients undergoing elective surgery: A systematic review, meta-analysis and meta-regression.","Systematic review of interventions","07 April 2025","08 April 2025","0","FALSE","Registered","United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251029748","retrieved","The Effects of GLP-1 Receptor Agonists on Alzheimer's Pathophysiology: A Systematic Review","Systematic review of interventions","26 April 2025","09 June 2025","0","FALSE","Registered","United Kingdom","A full protocol has not been written."],["CRD420251032222","retrieved","GLP-1 RAs Reduce Mortality and Cardiovascular Events Across the Spectrum of Treated Patients: A Systematic Review and Meta-Analysis","Systematic review of interventions","14 April 2025","17 April 2025","0","FALSE","Registered","Italy ; United States of America","A full protocol has been written but is not available because: The protocol entirely reflect that uploaded in PROSPERO"],["CRD420251034071","retrieved","The Effect of Semaglutide on Pancreatic β-Cell Function in Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis","Systematic review of interventions","20 April 2025","24 April 2025","0","FALSE","Registered","United States of America ; Germany ; Spain ; Japan ; China ; India ; Bangladesh ; Canada ; Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/067f9fb36088f0af70ba2ee2ae0f822b.pdf ."],["CRD420251034203","retrieved","Association of GLP-1 receptor agonists with risk of arthritis in patients with type 2 diabetes: a systematic review and network meta-analysis","Systematic review of interventions","16 April 2025","16 April 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251034652","retrieved","GLP-1 receptor agonists for the prevention of major cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease: systematic review and meta-analysis","Systematic review of interventions","17 April 2025","17 April 2025","0","FALSE","Registered","Colombia","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/595cec90dba001c12425747fd258cd50.pdf ."],["CRD420251037959","retrieved","Preventive Effects of SGLT2 Inhibitors on Dementia Compared to Incretins in Type 2 Diabetes: A systematic review and meta-analysis","Systematic review of interventions","24 April 2025","16 May 2025","0","FALSE","Registered","Korea, Republic of","A full protocol has not been written."],["CRD420251045294","retrieved","The Effects of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) on Alcohol-Related Outcomes: A Systematic Review and Meta-Analysis","Systematic review of interventions","03 May 2025","04 May 2025","0","FALSE","Registered","India","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251045700","retrieved","Efficacy and Safety of Novel Antidiabetic Drugs in Treating Polycystic Ovary Syndrome: A Network Meta - Analysis and Systematic Review.","Systematic review of interventions","04 May 2025","04 May 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251053598","retrieved","SGLT2i vs GLP-1 Management of Chronic Kidney Disease: Systematic Literature Review Protocol","Systematic review of interventions","09 June 2025","01 July 2025","0","FALSE","Registered","United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251054743","retrieved","Cardiac and renal safety of tirzepatide in participants with type 2 diabetes mellitus and obesity: systematic review and meta-analysis.","Systematic review of interventions","29 July 2025","04 August 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251055134","retrieved","Pharmacotherapy agents in prevention and treatment of secondary lymphedema: A systematic review","Systematic review of interventions","21 May 2025","15 January 2026","0","FALSE","Registered","United States of America","A full protocol has been written but is not available because: Available upon request. Please contact Lomm01@osumc.edu"],["CRD420251058602","retrieved","GLP-1 Analogues in Idiopathic Intracranial Hypertension: Systematic Review","Systematic review of interventions","22 May 2025","22 May 2025","0","FALSE","Registered","Brazil","A full protocol has not been written."],["CRD420251059430","retrieved","Semaglutide and risk of suicidal ideation and behaviour in adults with overweight or obesity, with or without type 2 diabetes: protocol for a systematic review and Bayesian meta-analysis","Systematic review of interventions","23 December 2025","30 December 2025","0","FALSE","Registered","Mexico","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/09655a5d5dbc1509748ba22fe79084c9.pdf ."],["CRD420251061447","retrieved","Impact of GLP-1 Receptor Agonist on Spine Surgery Outcomes: A Systematic Review","Systematic review of interventions","27 May 2025","05 June 2025","0","FALSE","Registered","United States of America ; Pakistan","A full protocol has not been written."],["CRD420251063158","retrieved","Efficacy of GLP-1 Receptor Agonist on Metabolic Parameters in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis","Systematic review of interventions","29 May 2025","29 May 2025","0","FALSE","Registered","Iran (Islamic Republic of)","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/5fee96825baaa1516dc6871b14f4964d.pdf ."],["CRD420251068833","retrieved","The correlation between novel antidiabetic agents utilization and hepatocellular carcinoma incidence in type 2 diabetes patients: a network meta-analysis and systematic review","Systematic review of interventions","06 June 2025","06 June 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251074381","retrieved","Are GLP-1 RA safe and efficient in the elderly?","Systematic review of interventions","15 June 2025","02 July 2025","0","FALSE","Registered","Portugal","A full protocol has not been written."],["CRD420251074882","retrieved","Glucagon-like peptide-1 receptor agonists for prevention of heart failure events in patients with type 2 diabetes and/or obesity: a systematic review and meta-analysis of randomised controlled trials","Systematic review of interventions","17 June 2025","19 June 2025","0","FALSE","Registered","United Kingdom","A full protocol has been written but is not available because: A full protocol will be made available on PROSPERO after completion of the review."],["CRD420251077610","retrieved","Differential Weight Loss Effects of Once-Weekly Semaglutide at 2.4 mg in Adults With and Without Type 2 Diabetes: A Systematic Review and Meta-Analysis","Systematic review of interventions","21 June 2025","23 June 2025","0","FALSE","Registered","Korea, Republic of","A full protocol has not been written."],["CRD420251077729","retrieved","Potential Protective Association of Antidiabetic and Lipid-Lowering Therapies on the Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis","Systematic review of interventions","20 June 2025","20 June 2025","0","FALSE","Registered","Saudi Arabia ; Canada","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251079970","retrieved","GLP‑1 Receptor Agonists in patients with heart failure: a meta-analysis of randomised controlled trials","Systematic review of interventions","24 June 2025","06 April 2026","0","FALSE","Registered","China ; Italy ; United States of America","A full protocol has not been written."],["CRD420251080120","retrieved","Ocular adverse events in diabetic or overweight/obese patients treated with Glucagon Like Peptide-1 receptor agonists (GLP-1 RAs): a systematic review and meta- analysis of observational studies","Systematic review of interventions","27 June 2025","27 June 2025","0","FALSE","Registered","Italy","A full protocol has not been written."],["CRD420251083622","retrieved","Efficacy and safety of Incretin-based treatment in patients with diabetes mellitus type 2 and peripheral arterial disease: A systematic review and meta-analysis","Systematic review of interventions","01 July 2025","01 July 2025","0","FALSE","Registered","Brazil","A full protocol has not been written."],["CRD420251086132","retrieved","Therapeutic Failures Associated with Semaglutide in Metabolic Diseases. Evidence from Randomized Controlled Trials","Systematic review of interventions","02 July 2025","02 July 2025","0","FALSE","Registered","United States of America","A full protocol has not been written."],["CRD420251088042","retrieved","Efficacy and Safety of GLP-1RAs in Patients with Cardiovascular and Renal Diseases: A Meta-Analysis","Systematic review of interventions","05 July 2025","05 July 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251090801","retrieved","Effects of glucagon-like peptide-1 receptor agonists on patients with metabolic dysfunction-associated steatohepatitis: a meta-analysis and systematic review","Systematic review of interventions","09 July 2025","09 July 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251107346","retrieved","Semaglutide Use and the Risk of Developing Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION): A Systematic Review and Meta-Analysis","Systematic review of interventions","18 July 2025","18 July 2025","0","FALSE","Registered","Iraq ; Qatar ; United States of America","A full protocol has been written but is not available because: A full protocol has not been written."],["CRD420251107996","retrieved","Efficacy and safety of oral hypoglycemic drugs as adjunctive therapy to automated insulin delivery system in type 1 diabetes: A systematic review and meta-analysis of randomized clinical trials","Systematic review of interventions","22 July 2025","24 July 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251110220","retrieved","Beyond Weight Loss - A Systematic Review of the Clinical Impact of GLP-1 Receptor Agonists in Hidradenitis Suppurativa","Systematic review of interventions","24 October 2025","24 October 2025","0","FALSE","Registered","Ireland ; Romania","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251111692","retrieved","Perioperative GLP‑1 Receptor Agonists in Adult Spine Surgery: A Systematic Review of Clinical, Healing, and Recovery Outcomes","Systematic review of interventions","24 July 2025","24 July 2025","0","FALSE","Registered","United States of America","A full protocol has not been written."],["CRD420251112823","retrieved","Association of glucagon-like peptide 1 receptor agonists with diverse health outcomes in type 2 diabetes","Systematic review of interventions","25 July 2025","26 July 2025","0","FALSE","Registered","Korea, Republic of","A full protocol has not been written."],["CRD420251118829","retrieved","Effects of GLP-1 receptor agonists on antipsychotic-induced weight gain: A meta-analysis","Systematic review of interventions","19 August 2025","19 August 2025","0","FALSE","Registered","Korea, Republic of","A full protocol has not been written."],["CRD420251128528","retrieved","Cagrilintide–Semaglutide Combination Therapy Versus Monotherapy or Placebo: A Systematic Review and Bayesian Meta-Analysis","Systematic review of interventions","19 August 2025","22 August 2025","0","FALSE","Registered","Mexico ; Brazil ; Peru","A full protocol has not been written."],["CRD420251130232","retrieved","A systemtatic review and (network) meta-analysis on the risk of Parkinson's disease in diabetic patients","Systematic review of interventions","20 August 2025","20 August 2025","0","FALSE","Registered","Korea, Republic of","A full protocol has been written but is not available because: All key methodological elements will be described in the manuscript and will be uploaded after the review is completed."],["CRD420251138529","retrieved","Efficacy and safety of GLP-1 receptor agonists in adults with HFpEF vs HFrEF: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","01 September 2025","01 September 2025","0","FALSE","Registered","Pakistan","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/8b82443ae273f72801c50b4be4c62a41.pdf ."],["CRD420251139475","retrieved","Economic Evaluations of Anti-Obesity Medications: A Systematic Literature Review","Systematic review of interventions","02 September 2025","08 September 2025","0","FALSE","Registered","Croatia ; Canada ; Bosnia and Herzegovina","A full protocol has not been written."],["CRD420251143171","retrieved","Glucagon-Like Peptide-1 Receptor Agonists in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Cognitive and Metabolic Outcomes","Systematic review of interventions","08 September 2025","09 September 2025","0","FALSE","Registered","Brazil","A full protocol has not been written."],["CRD420251146144","retrieved","Efficacy and safety of novel hypoglycemic agents in patients with Type 2 diabetes and chronic kidney disease: a network meta-analysis","Systematic review of interventions","23 September 2025","26 September 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251146788","retrieved","Risk–Benefit Trade-offs of GLP-1RAs and SGLT-2is in Type 2 Diabetes Mellitus (T2D): Systematic Review, Meta-Analysis, and Net Benefit Modelling","Systematic review of interventions","13 September 2025","13 September 2025","0","FALSE","Registered","India ; United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251147337","retrieved","Effects of Subcutaneous Injection or Oral Semaglutide on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","16 September 2025","16 September 2025","0","FALSE","Registered","China","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251149266","retrieved","Antidiabetic medications and the risk of bladder cancer in patients with diabetes mellitus: A systematic review and meta-analysis","Systematic review of interventions","17 September 2025","17 September 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251150683","retrieved","Comparison of GLP-1RAs, SGLT2is, and nsMRA for Cardiovascular and Renal Benefits in T2DN: A Network Meta-Analysis","Systematic review of interventions","19 September 2025","19 September 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251151419","retrieved","Reassessing the Risks of Hematologic Malignancies Prevention associated with Novel Antidiabetic Agents: Histopathology-Based Network Meta-Analysis","Systematic review of interventions","19 September 2025","19 September 2025","0","FALSE","Registered","Taiwan (R.O.C.)","A full protocol has been written but is not available because: The current protocol was not available due to avoiding risk of plagiarism"],["CRD420251152746","retrieved","Efficacy and Safety of Incretin-Based Therapies for Type 2 Diabetes Mellitus: A Network Meta-Analysis Based on Clinical Trials","Systematic review of interventions","22 September 2025","22 September 2025","0","FALSE","Registered","China","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251153352","retrieved","Clinical Outcomes of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Kidney Transplant Recipients: A Systematic Review and Meta-analysis","Systematic review of interventions","22 September 2025","22 September 2025","0","FALSE","Registered","Türkiye","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251154851","retrieved","Safety and Efficacy of Tirzepatide in Transplant Recipients: A Systematic Review and Meta-Analysis","Systematic review of interventions","25 September 2025","25 September 2025","0","FALSE","Registered","Italy ; United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251155026","retrieved","Semaglutide and risk of non-arteritic anterior ischemic optic neuropathy: A systematic review and meta-analysis","Systematic review of interventions","27 September 2025","27 September 2025","0","FALSE","Registered","Greece","A full protocol has been written but is not available because: The full protocol will be available once the paper has been published."],["CRD420251157476","retrieved","Inflammatory Biomarker Response to GLP-1 Receptor Agonists versus other Glucose-Lowering Medications in Patients with Type 2 Diabetes (T2D): A Systematic Review and Meta-analysis","Systematic review of interventions","28 September 2025","03 October 2025","0","FALSE","Registered","Saudi Arabia","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/4098d5beedf4bd8713037c0a87c1fafd.pdf ."],["CRD420251158592","retrieved","Novel Antidiabetic Agents and the Risk of Respiratory Diseases: A Systematic Review and Meta-Analysis of 27 Randomized Controlled Trials","Systematic review of interventions","30 September 2025","30 September 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251162316","retrieved","Effects of GLP1-receptor agonist and dual GLP1-receptor agonist/GIP on liver steatosis evaluated through ultrasound methods: a systematic review and meta-analysis","Systematic review of interventions","08 October 2025","09 October 2025","0","FALSE","Registered","Italy","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251165267","retrieved","Comparative Efficacy and Safety of SGLT-2i, GLP-1 RA and Tirzepatide in the management of obstructive sleep apnea: a systematic review, meta-analysis and network meta-analysis","Systematic review of interventions","10 October 2025","10 October 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251168485","retrieved","SGLT2 Inhibitors versus GLP-1 Receptor Agonists for Major Adverse Cardiovascular Events in Type 2 Diabetes: A Systematic Review and Meta-Analysis","Systematic review of interventions","15 October 2025","15 October 2025","0","FALSE","Registered","Sudan ; United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251170117","retrieved","Efficacy and Safety of Tirzepatide in Patients with Heart Failure with Preserved Ejection Fraction: A Meta-Analysis","Systematic review of interventions","16 October 2025","16 October 2025","0","FALSE","Registered","United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251170531","retrieved","Glucagon-like peptide-1 Receptor Agonists in Parkinson's Disease: A Meta-Analysis Confirming Motor and Non-motor Efficacy and Exploring Adverse Events","Systematic review of interventions","02 November 2025","20 November 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251174653","retrieved","Management of Overweight, Obesity, and Cardiometabolic Comorbidities in Inflammatory Bowel Disease: A Systematic Review","Systematic review of interventions","02 November 2025","17 December 2025","0","FALSE","Registered","United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/68651204d960b39a35b42944ac12a80e.pdf ."],["CRD420251176164","retrieved","Incidence of Diabetic Macular Edema (DME) Associated with GLP-1 Receptor Agonist Use: A Systematic Review","Systematic review of interventions","25 October 2025","25 October 2025","0","FALSE","Registered","Canada","A full protocol has been written but is not available because: The full protocol will be submitted for peer-reviewed publication following PROSPERO registration. Until acceptance, the complete document is available upon reasonable request from the corresponding author."],["CRD42025117631","not found",null,null,null,null,null,null,null,null,null],["CRD420251177261","retrieved","GLP-1 Analogs in Patients with Schizophrenia: A systematic review and meta-analysis","Systematic review of interventions","11 December 2025","11 December 2025","0","FALSE","Registered","Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251177348","retrieved","Meta-Analysis of GLP1R, GIPR, ADCY3, and CREB1 Expression in Osteoarthritis Identifies CREB1 as a Potential Biomarker and Therapeutic Target","Systematic review of interventions","27 October 2025","27 October 2025","0","FALSE","Registered","Taiwan (R.O.C.)","A full protocol has not been written."],["CRD420251178714","retrieved","First-Line Treatment Strategies for Drug-Naïve Type 2 Diabetes: A Network Meta-Analysis of SGLT2 Inhibitors, GLP-1 RAs, and SGLT2i plus Metformin","Systematic review of interventions","15 December 2025","15 December 2025","0","FALSE","Registered","United States of America","A full protocol has been written but is not available because: The full protocol will not be made publicly available due to concerns regarding potential data misuse and to protect the originality of the planned analyses prior to publication."],["CRD420251178799","retrieved","A Systematic Review of Cardiometabolic Complications in Inflammatory Bowel Disease","Systematic review of interventions","28 October 2025","18 November 2025","0","FALSE","Registered","United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251178843","retrieved","A systematic review of the impact of obesity on inflammatory bowel disease outcomes","Systematic review of interventions","03 November 2025","18 November 2025","0","FALSE","Registered","United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251181076","retrieved","Dietary strategies and nutritional management in patients treated with GLP-1 receptor agonists: a systematic review of randomized clinical trials","Systematic review of interventions","31 October 2025","31 October 2025","0","FALSE","Registered","Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251183082","retrieved","Efficacy and safety of GLP-1 receptor agonists therapy in Steroid-Induced Diabetes - a systematic review","Systematic review of interventions","07 November 2025","07 November 2025","0","FALSE","Registered","Poland","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251183938","retrieved","Association Between Glucagon-Like Peptide-1 Receptor Agonist Use and Risk of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis","Systematic review of interventions","04 November 2025","04 November 2025","0","FALSE","Registered","Canada","A full protocol has been written but is not available because: A full protocol has been written but is not publicly available at this time because it will be submitted for peer-reviewed publication following PROSPERO registration. Until publication, the complete protocol is available upon reasonable request from the corresponding author."],["CRD420251229397","retrieved","Efficacy and Safety of Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, on Cardiometabolic Outcomes: A Systematic Review and Meta-Analysis","Systematic review of interventions","11 November 2025","11 November 2025","0","FALSE","Registered","United States of America ; Hungary ; Poland ; Slovakia ; China ; India ; Japan ; Mexico ; Korea, Republic of ; Brazil ; Spain ; Taiwan (R.O.C.)","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251230032","retrieved","THR-β Agonism vs Incretin Therapies for Non-Cirrhotic MASH: A Biopsy-Anchored Systematic Review with GRADE Certainty","Systematic review of interventions","22 November 2025","22 November 2025","0","FALSE","Registered","United States of America ; Canada ; United Kingdom ; Spain ; Israel ; Mexico ; France ; Germany ; Italy ; Poland ; Austria ; Switzerland ; Belgium","A full protocol has been written but is not available because: The full protocol is not being made available because it is currently in a draft stage and has not yet been finalized or formally published. It is being used internally to guide the systematic review, but no external version is ready for dissemination at this time."],["CRD420251231137","retrieved","SGLT2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors on Cardiovascular and Hepatic Outcomes in Asian versus White Patients with Type 2 Diabetes and NAFLD: A Systematic Review and Network Meta-Analysis","Systematic review of interventions","15 November 2025","15 November 2025","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420251237462","retrieved","GLP-1 Receptor Agonists and Dual GIP/GLP-1 Agonists and the Risk of Heart Failure Hospitalization in Obese Patients With HFpEF: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","Systematic review of interventions","23 November 2025","23 November 2025","0","FALSE","Registered","Saudi Arabia","A full protocol has not been written."],["CRD420251237987","retrieved","GLP-1 Receptor Agonists and Diabetic Retinopathy: A Systematic Review and Qualitative Evidence Synthesis","Systematic review of interventions","22 November 2025","03 December 2025","0","FALSE","Registered","Portugal","A full protocol has been written but is not available because: The full protocol is complete but has not been submitted for publication and is currently undergoing internal review. It will be made available upon journal submission or upon request."],["CRD420251243172","retrieved","Systematic review and Meta-analysis of the effects of GLP-1 receptor agonists on cardiometabolic outcomes in heart-transplant recipients","Systematic review of interventions","30 November 2025","30 November 2025","0","FALSE","Registered","United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/8d907c8d3c12036cd2ed0c9f9fb4ea50.pdf ."],["CRD420251248437","retrieved","Semaglutide and Other GLP-1 Agonists for Antipsychotic-Associated Metabolic Dysfunction in Schizophrenia: A Systematic Review and Meta-Analysis","Systematic review of interventions","07 December 2025","07 December 2025","0","FALSE","Registered","Pakistan","A full protocol has not been written."],["CRD420251251321","retrieved","A Systematic review and meta analysis on use of GLP-1 agonists in post bariatric surgery patients","Systematic review of interventions","17 December 2025","13 December 2025","0","FALSE","Registered","India ; Brazil ; Pakistan ; Georgia ; United Arab Emirates","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251270326","retrieved","Cardiovascular Outcomes Associated With GLP-1 Receptor Agonists in Patients With Type 2 Diabetes and a History of Myocardial Infarction: A Systematic Review and Time-to-Event Meta-Analysis","Systematic review of interventions","20 December 2025","21 December 2025","0","FALSE","Registered","Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420251276594","retrieved","Title: Efficacy and safety of tirzepatide versus dulaglutide in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","31 December 2025","31 December 2025","0","FALSE","Registered","Pakistan","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/b6ba229dd3287a91f2746ed702549415.pdf ."],["CRD42025628850","retrieved","Efficacy and Safety of GLP-1-Based Therapies in Inflammatory Bowel Disease","Systematic review of interventions","30 January 2025","10 February 2025","0","FALSE","Registered","Canada","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/4a9aa443ba9b0052712ff71aa9c287a6.pdf ."],["CRD42025631539","retrieved","Effects of pharmacological blood pressure lowering in heart failure with mildly reduced or preserved ejection fraction","Systematic review of interventions","05 February 2025","16 February 2025","2","FALSE","Registered","Australia",null],["CRD42025633998","retrieved","A Systematic Review and Meta-Analysis of the Impact of Tirzepatide on Glycemic Control and Body Weight in Type 1 Diabetes Mellitus.","Systematic review of interventions","14 January 2025","27 January 2025","2","FALSE","Registered","Egypt",null],["CRD42025636991","retrieved","Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: A Bayesian network meta-analysis","Systematic review of interventions","11 January 2025","22 January 2025","3","FALSE","Registered","China",null],["CRD42025637054","retrieved","Efficacy of tirzepatide, lanifibranor, or resmetirom for treatment of non-alcoholic fatty liver disease: a meta-analysis","Systematic review of interventions","12 January 2025","23 January 2025","0","FALSE","Registered","China",null],["CRD42025637238","retrieved","Liraglutide for Weight Loss in Non-Diabetic Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis of Clinical Trials","Systematic review of interventions","11 January 2025","22 January 2025","0","FALSE","Registered","Ecuador",null],["CRD42025640318","retrieved","Comparative effectiveness of GLP-1 receptor agonists and their dual agonists in the treatment of patients with metabolic dysfunction-associated steatohepatitis: systematic review and meta-analysis","Systematic review of interventions","19 January 2025","29 January 2025","0","FALSE","Registered","China",null],["CRD42025641616","retrieved","Do Incretin-Based Therapies Influence the Risk of Cholangiocarcinoma in Type 2 Diabetes? Insights from a Systematic Review and Meta-Analysis","Systematic review of interventions","21 January 2025","01 February 2025","2","FALSE","Registered","Indonesia",null],["CRD42025644064","retrieved","Association between Metabolic (Dysfunction) Associated Steatotic Liver Disease (MASLD) and Heart Failure with Preserved Ejection Fraction (HFpEF): A Systematic Review and Meta-Analysis.","Systematic review of interventions","28 January 2025","08 February 2025","2","FALSE","Registered","Egypt, Tunisia",null],["CRD42025645378","retrieved","The Impact of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists on Body Composition in Individuals without Type 2 Diabetes: A systemic review and meta-analysis","Systematic review of interventions","07 February 2025","18 February 2025","2","FALSE","Registered","Poland",null],["CRD42025646185","retrieved","Efficacy of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists After Cessation: A Systematic Review and Meta-Analysis","Systematic review of interventions","03 February 2025","13 February 2025","0","FALSE","Registered","Taiwan",null],["CRD42025649542","retrieved","GLP-1 Receptor Agonist-Induced Non-arteritic Anterior Ischemic Optic Neuropathy; A Systematic Review and Meta-analysis","Systematic review of interventions","08 February 2025","19 February 2025","2","FALSE","Registered","Iran",null],["CRD42025649619","retrieved","Umbrella Review of Systematic Reviews and Meta-Analyses on Interventions for Pre-Diabetes","Systematic review of interventions","08 February 2025","19 February 2025","2","FALSE","Registered","Italy",null],["CRD42025650082","retrieved","Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists in Idiopathic Intracranial Hypertension: a systematic review and meta-analysis","Systematic review of interventions","09 February 2025","20 February 2025","2","FALSE","Registered","Greece",null],["CRD420261277032","retrieved","GLP-1 Receptor Agonists and Neuroprotection in Neurodegenerative Disorders and Mild Cognitive Impairment","Systematic review of interventions","02 January 2026","02 January 2026","0","FALSE","Registered","Korea, Republic of","A full protocol has not been written."],["CRD420261279841","retrieved","Comparative efficacy and safety of GLP-1–based pharmacotherapies for weight loss in adults with overweight or obesity without diabetes: a systematic review and network meta-analysis of randomised controlled trials","Systematic review of interventions","06 January 2026","06 January 2026","0","FALSE","Registered","China","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261282728","retrieved","Gastric Tumor Risk With Newer Antidiabetic Agents","Systematic review of interventions","10 January 2026","10 January 2026","0","FALSE","Registered","Taiwan (R.O.C.)","A full protocol has been written but is not available because: The full protocol has been written but is not available due to avoid risk of plagiarism"],["CRD420261287573","retrieved","GLP-1 receptor agonists in metabolic dysfunction-associated steatohepatitis: protocol for a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","17 January 2026","17 January 2026","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420261288562","retrieved","Clinical Evidence of Semaglutide for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An Updated Meta-analysis","Systematic review of interventions","19 January 2026","19 January 2026","0","FALSE","Registered","Taiwan (R.O.C.)","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261292638","retrieved","Updating the MASH Pharmacotherapy Landscape: A Network Meta-Analysis Incorporating SGLT2 Inhibitors and Emerging Combination Therapies","Systematic review of interventions","24 January 2026","24 January 2026","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420261297384","retrieved","GLP-1 receptor agonists and hair loss: a systematic review in the era of anti-obesity therapeutics","Systematic review of interventions","02 February 2026","02 February 2026","0","FALSE","Registered","Canada","A full protocol has been written but is not available because: Protocol will be published with the manuscript"],["CRD420261299499","retrieved","Comparative effectiveness of GLP-1 receptor agonist–based therapies for hard liver outcomes in adults with type 2 diabetes: systematic review of real-world evidence and target-trial emulations","Systematic review of interventions","02 February 2026","02 February 2026","0","FALSE","Registered","Taiwan (R.O.C.)","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261299756","retrieved","Comparative Cardiovascular Efficacy of SGLT2 Inhibitors versus GLP-1 Receptor Agonists in Type 2 Diabetes Patients with Recent Myocardial Infarction: A Systematic Review and Meta-Analysis","Systematic review of interventions","02 February 2026","02 February 2026","0","FALSE","Registered","China","A full protocol has been written but is not available because: Protocol is currently under internal institutional review and will be submitted for publication following registration completion."],["CRD420261305875","retrieved","Pulmonary adverse events associated with GLP-1 receptor agonists: A Systematic review of respiratory safety signals","Systematic review of interventions","10 February 2026","18 February 2026","0","FALSE","Registered","India","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261305938","retrieved","Effects of Glucagon-Like Peptide-1 Receptor Agonists on Stroke and Cognitive Outcomes: A Systematic Review and Meta-Regression","Systematic review of interventions","10 February 2026","18 February 2026","0","FALSE","Registered","United Kingdom","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261306111","retrieved","Cardiovascular outcomes in diabetic patients treated with SGLT2i and GLP1-RA: a systematic review and meta-analysis","Systematic review of interventions","18 February 2026","18 February 2026","0","FALSE","Registered","Italy","A full protocol has been written but is not available because: Protocol is not available in PDF format."],["CRD420261320374","retrieved","Cardiovascular Outcomes Associated with Combination Therapy Using Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists Compared with Monotherapy in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis","Systematic review of interventions","18 February 2026","21 February 2026","0","FALSE","Registered","Iran (Islamic Republic of)","A full protocol has not been written."],["CRD420261320840","retrieved","Combination of sodium glucose cotransporter-2 inhibitor and glucagon-like peptide-1 receptor agonist in patients with baseline heart failure","Systematic review of interventions","18 February 2026","18 February 2026","0","FALSE","Registered","Indonesia","A full protocol has been written but is not available because: We intend not to publish the protocol, but only publish the result of the study"],["CRD420261321430","retrieved","Effects of Glucagon-Like Peptide-1 Receptor and dual GIP/GLP-1 Agonists on Inflammatory Biomarkers: A Systematic Review and Meta-Analysis","Systematic review of interventions","21 March 2026","21 March 2026","0","FALSE","Registered","Türkiye","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/fd420e40540b2e281ef1800229695284.pdf ."],["CRD420261323497","retrieved","Composition of Incretin-Induced Weight Loss: A Systematic Review and Meta-Analysis of DXA-Measured Lean and Fat Mass","Systematic review of interventions","23 March 2026","23 March 2026","0","FALSE","Registered","Türkiye","A full protocol has not been written."],["CRD420261327235","retrieved","Comparative Efficacy and Safety of Ecnoglutide in Type 2 Diabetes: A Systematic Review and Meta-Analysis Incorporating Dose- and Time-Response Analyses","Systematic review of interventions","27 February 2026","27 February 2026","0","FALSE","Registered","China","A full protocol has been written but is not available because: The full protocol is not publicly available as this review is part of an ongoing research project and the authors intend to submit the complete protocol alongside the final manuscript for peer-reviewed publication. However, all key methodological details are fully described within this PROSPERO registration to ensure transparency and reproducibility."],["CRD420261335230","retrieved","Tirzepatide as Adjunct to Insulin in Adults With Type 1 Diabetes and Overweight or Obesity: A Systematic Review of Randomized and Real-World Evidence","Systematic review of interventions","08 March 2026","08 March 2026","0","FALSE","Registered","Italy","A full protocol has been written but is not available because: A full protocol was prepared prospectively prior to study initiation, documenting: - Review question/PICO - Search strategy (5 databases + ClinicalTrials.gov) - Eligibility criteria - Primary/secondary outcomes - Risk-of-bias tools (RoB 2, ROBINS-I) - Pre-planned qualitative synthesis (no meta-analysis due to expected heterogeneity) Full protocol available from corresponding author upon request."],["CRD420261335458","retrieved","GLP-1 Receptor Agonists and Alopecia: A Systematic Review and Meta-Analysis of Incidence, Risk, Subtypes, and Mechanisms","Systematic review of interventions","09 March 2026","09 March 2026","0","FALSE","Registered","Mexico","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/c7a0996f1d1aa2ad3b8c01a15a8be428.pdf ."],["CRD420261337353","retrieved","Clinical Impact of GLP-1 Receptor Agonists on Liver Disease Outcomes in Non-Alcoholic Fatty Liver Disease: A Systematic Review","Systematic review of interventions","11 March 2026","16 March 2026","0","FALSE","Registered","Bahrain","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/e87018e0288c14c4943eec3b4e434c99.pdf ."],["CRD420261340457","retrieved","Novel amylin-based therapies for weight management in adults with overweight or obesity without diabetes: a network meta-analysis","Systematic review of interventions","14 March 2026","14 March 2026","0","FALSE","Registered","Bangladesh","A full protocol has not been written."],["CRD420261352699","retrieved","Effects of renin-angiotensin inhibitors, SGLT2 inhibitors, mineralocorticoid receptor antagonists & GLP-1 receptor agonists on cardiovascular & kidney outcomes in patients with type 1 diabetes: A systematic review & meta-analysis","Systematic review of interventions","04 May 2026","04 May 2026","0","FALSE","Registered","Canada ; United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261354386","retrieved","Risk of neoplasms with semaglutide in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials","Systematic review of interventions","29 March 2026","29 March 2026","0","FALSE","Registered","China","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/d2db2b781a168342e1540871336509a4.pdf ."],["CRD420261354941","retrieved","Cardiovascular Outcomes with Tirzepatide versus GLP-1 Receptor Agonists in Adults with Obesity: A Systematic Review and Meta-Analysis","Systematic review of interventions","31 March 2026","02 April 2026","0","FALSE","Registered","Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/8176e4696b7a657d5a7772dfc3a582c3.pdf ."],["CRD420261360837","retrieved","Effect of GLP-1 receptor agonists combined with structured exercise and diet on fat-free mass in adults with obesity or type 2 diabetes: a systematic review and meta-analysis","Systematic review of interventions","05 April 2026","05 April 2026","0","FALSE","Registered","Chile","A full protocol has been written and uploaded to PROSPERO. The protocol will be made available after the review is completed."],["CRD420261360886","retrieved","Efficacy and safety of glucagon-like peptide-1 receptor agonists for diabetic cardiomyopathy: protocol for a systematic review and meta-analysis","Systematic review of interventions","05 April 2026","05 April 2026","0","FALSE","Registered","China","A full protocol has not been written."],["CRD420261361351","retrieved","Comparative Efficacy and Safety of Tirzepatide in Asian and Non‑Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta‑Analysis","Systematic review of interventions","06 April 2026","06 April 2026","0","FALSE","Registered","Bangladesh","A full protocol has not been written."],["CRD420261367140","retrieved","Effects of pharmacological and non-pharmacological interventions on epicardial adipose tissue: a systematic review and meta-analysis with comparison to BMI changes","Systematic review of interventions","12 April 2026","12 April 2026","0","FALSE","Registered","Poland","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/a0238209160ec1f9e1e3b7aa8f79968b.pdf ."],["CRD420261385854","retrieved","GLP-1 Receptor Agonists in Multiple Sclerosis: A Systematic Review of Preclinical and Clinical Evidence","Systematic review of interventions","03 May 2026","03 May 2026","0","FALSE","Registered","Pakistan","A full protocol has not been written."],["CRD420261411693","retrieved","Body Composition Outcomes During GLP-1-Based Therapy: A Systematic Review and Meta-analysis","Systematic review of interventions","31 May 2026","01 June 2026","0","FALSE","Registered","Brazil ; Chile","A full protocol has been written but is not available because: The review is currently ongoing, and the full protocol is being finalised. Key methodological details are provided in this PROSPERO record to ensure transparency. The full protocol may be made available upon reasonable request after completion of the review."],["CRD420261414637","retrieved","Do Preoperative GLP-1 Receptor Agonists Influence Lumbar Fusion Outcomes? A Systematic Review and Meta-Analysis","Systematic review of interventions","03 June 2026","13 June 2026","0","FALSE","Registered","United States of America ; Brazil","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/c643fdc6c79e67d68338b5a174e0a6c5.pdf ."],["CRD420261425340","retrieved","Positioning of Next-Generation Obesity Management Medications: a series of systematic reviews and network meta-analyses of approved and investigational anti-obesity pharmacotherapies.","Systematic review of interventions","17 June 2026","17 June 2026","0","FALSE","Registered","Italy","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/b3a72da014954738096a077f10310469.pdf ."],["CRD420261435182","retrieved","Comparative efficacy, Safety, Menstrual cycle regulation and Weight Outcomes of Liraglutide Versus Metformin in women with Polyendocrine Metabolic Ovarian Syndrome (PMOS) : A Systematic Review and Meta-analysis.","Systematic review of interventions","27 June 2026","27 June 2026","0","FALSE","Registered","India ; Mauritius ; South Africa ; United States of America","A full protocol has been written and uploaded to PROSPERO. The protocol may be accessed through this link https://www.crd.york.ac.uk/PROSPEROFILES/0926bbb19b124194e92265064bbfbb89.pdf ."],["CRD420261456447","retrieved","Dual Glucagon-Like Peptide-1/Glucagon Receptor Agonists for Obesity and Overweight: A Systematic Review and Meta-Analysis","Systematic review of interventions","20 July 2026","20 July 2026","0","FALSE","Registered","Pakistan","A full protocol has not been written."]]}