# Search concepts for the living review of GLP-1 receptor agonist containing drugs.
#
# One file defines every term once. R/search_strategy.R renders it into the
# native syntax of each source, and every run writes the rendered query next to
# its results, so the exact string sent to each API is always on record.
#
# version: bumped whenever a term is added or removed. A change is a protocol
# amendment and is logged in protocol/amendments.csv.
version: 1.0.0
date: 2026-10-12

intervention:
  # Class level terms. Phrases are searched as phrases; a trailing * truncates
  # where the source supports it and is dropped where it does not.
  class:
    - "glucagon-like peptide-1 receptor agonist*"
    - "glucagon-like peptide 1 receptor agonist*"
    - "glucagon like peptide 1 receptor agonist*"
    - "GLP-1 receptor agonist*"
    - "GLP-1R agonist*"
    - "GLP-1 RA"
    - "GLP-1 RAs"
    - "GLP-1RA*"
    - "GLP1RA*"
    - "GLP-1 agonist*"
    - "GLP1 agonist*"
    - "GLP-1 analog*"
    - "GLP-1 analogue*"
    - "glucagon-like peptide-1 analog*"
    - "glucagon-like peptide-1 analogue*"
    - "incretin mimetic*"
    - "incretin-based therap*"
    - "incretin based therap*"
    - "GIP/GLP-1 receptor agonist*"
    - "GLP-1/GIP receptor agonist*"
    - "GLP-1/glucagon receptor agonist*"
    - "glucagon/GLP-1 receptor agonist*"

  # Agents: generic names, brand names and development codes. Each agent maps
  # to a node family in protocol/nodes.csv.
  agents:
    semaglutide: [semaglutide, Ozempic, Wegovy, Rybelsus, NN9535, "NN-9535", NN9536, "NN-9536", NN9924, "NNC0113-0217"]
    liraglutide: [liraglutide, Victoza, Saxenda, NN2211, "NN-2211", "NNC 90-1170"]
    dulaglutide: [dulaglutide, Trulicity, LY2189265]
    exenatide: [exenatide, Byetta, Bydureon, exendin-4, "exendin 4", AC2993, "AC 2993", "ITCA 650", ITCA650]
    lixisenatide: [lixisenatide, Lyxumia, Adlyxin, AVE0010, "AVE 0010"]
    albiglutide: [albiglutide, Tanzeum, Eperzan]
    taspoglutide: [taspoglutide]
    efpeglenatide: [efpeglenatide, HM11260C]
    beinaglutide: [beinaglutide]
    loxenatide: [loxenatide, "PEG-loxenatide", "polyethylene glycol loxenatide"]
    ecnoglutide: [ecnoglutide, XW003]
    supaglutide: [supaglutide]
    efsubaglutide: [efsubaglutide]
    glutazumab: [glutazumab, GMA102]
    bofanglutide: [bofanglutide]
    dapiglutide: [dapiglutide]
    tirzepatide: [tirzepatide, Mounjaro, Zepbound, LY3298176]
    retatrutide: [retatrutide, LY3437943]
    survodutide: [survodutide, "BI 456906", BI456906]
    mazdutide: [mazdutide, IBI362, LY3305677]
    cotadutide: [cotadutide, MEDI0382]
    efinopegdutide: [efinopegdutide, "MK-6024", HM12525A]
    pemvidutide: [pemvidutide, "ALT-801"]
    orforglipron: [orforglipron, LY3502970]
    danuglipron: [danuglipron, "PF-06882961"]
    lotiglipron: [lotiglipron, "PF-07081532"]
    aleniglipron: [aleniglipron, "GSBR-1290"]
    cagrilintide_semaglutide: [CagriSema, cagrilintide]
    amycretin: [amycretin]
    maridebart_cafraglutide: [maridebart, MariTide, "AMG 133"]
    vk2735: [VK2735]
    hrs9531: [HRS9531, "HRS-9531", "HRS-7535", HRS7535]
    insulin_degludec_liraglutide: [IDegLira, Xultophy, "insulin degludec/liraglutide"]
    insulin_glargine_lixisenatide: [iGlarLixi, Soliqua, Suliqua, "insulin glargine/lixisenatide", LixiLan]
    insulin_icodec_semaglutide: [IcoSema, "insulin icodec/semaglutide"]

  # Controlled vocabulary, PubMed only. The endogenous hormone heading
  # ("Glucagon-Like Peptide 1") and the receptor heading are deliberately left
  # out: they retrieve physiology without adding drug studies, which carry the
  # drug name in the title or abstract.
  pubmed_mesh:
    - '"Glucagon-Like Peptide-1 Receptor Agonists"[Mesh]'
    - '"Glucagon-Like Peptide-1 Receptor Agonists"[pa]'
    - '"Liraglutide"[Mesh]'
    - '"Exenatide"[Mesh]'
    - 'semaglutide[nm]'
    - 'tirzepatide[nm]'
    - 'dulaglutide[nm]'
    - 'lixisenatide[nm]'
    - 'albiglutide[nm]'
    - 'taspoglutide[nm]'
    - 'efpeglenatide[nm]'
    - 'survodutide[nm]'
    - 'insulin degludec, liraglutide drug combination[nm]'
    - 'insulin glargine, lixisenatide drug combination[nm]'

# No design, language or date limits are applied at the search stage. Every
# record is classified afterwards (R/classify.R) so that the inventory keeps
# trials, observational studies, systematic reviews and protocols alike.
limits: none